Nutrients (May 2018)
Circulating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort
- Eline H. van Roekel,
- Laura Trijsburg,
- Nada Assi,
- Marion Carayol,
- David Achaintre,
- Neil Murphy,
- Sabina Rinaldi,
- Julie A. Schmidt,
- Magdalena Stepien,
- Rudolf Kaaks,
- Tilman Kühn,
- Heiner Boeing,
- Khalid Iqbal,
- Domenico Palli,
- Vittorio Krogh,
- Rosario Tumino,
- Fulvio Ricceri,
- Salvatore Panico,
- Petra H. Peeters,
- Bas Bueno-de-Mesquita,
- Eva Ardanaz,
- Leila Lujan-Barroso,
- J. Ramón Quirós,
- José M. Huerta,
- Elena Molina-Portillo,
- Miren Dorronsoro,
- Konstantinos K. Tsilidis,
- Elio Riboli,
- Agnetha Linn Rostgaard-Hansen,
- Anne Tjønneland,
- Kim Overvad,
- Elisabete Weiderpass,
- Marie-Christine Boutron-Ruault,
- Gianluca Severi,
- Antonia Trichopoulou,
- Anna Karakatsani,
- Anastasia Kotanidou,
- Anders Håkansson,
- Johan Malm,
- Matty P. Weijenberg,
- Marc J. Gunter,
- Mazda Jenab,
- Mattias Johansson,
- Ruth C. Travis,
- Augustin Scalbert,
- Pietro Ferrari
Affiliations
- Eline H. van Roekel
- Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, 6229 HA Maastricht, The Netherlands
- Laura Trijsburg
- Nutritional Methodology and Biostatistics Group, Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France
- Nada Assi
- Nutritional Methodology and Biostatistics Group, Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France
- Marion Carayol
- Epidaure, Prevention Department of the Institut régional du Cancer de Montpellier (ICM), 34298 Montpellier, France
- David Achaintre
- Biomarkers Group, Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France
- Neil Murphy
- Nutritional Epidemiology Group, Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France
- Sabina Rinaldi
- Biomarkers Group, Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France
- Julie A. Schmidt
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK
- Magdalena Stepien
- Nutritional Epidemiology Group, Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France
- Rudolf Kaaks
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
- Tilman Kühn
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
- Heiner Boeing
- Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany
- Khalid Iqbal
- Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany
- Domenico Palli
- Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute—ISPO, 50141 Florence, Italy
- Vittorio Krogh
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
- Rosario Tumino
- Cancer Registry and Histopathology Department, Civic—M.P.Arezzo Hospital, ASP, 97100 Ragusa, Italy
- Fulvio Ricceri
- Department of Clinical and Biological Sciences, University of Turin, 10124 Turin, Italy
- Salvatore Panico
- Dipartimento di Medicina Clinica e Chirurgia, Federico II University, 80138 Naples, Italy
- Petra H. Peeters
- Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, 3508 GA Utrecht, The Netherlands
- Bas Bueno-de-Mesquita
- Former Senior Scientist, Dept. for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), 3721 MA Bilthoven, The Netherlands
- Eva Ardanaz
- Navarra Public Health Institute, 31003 Pamplona, Spain
- Leila Lujan-Barroso
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat, 08908 Barcelona, Spain
- J. Ramón Quirós
- Public Health Directorate, 33005 Oviedo, Spain
- José M. Huerta
- CIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
- Elena Molina-Portillo
- CIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
- Miren Dorronsoro
- Basque Regional Health Department, Public Health Direction and Biodonostia Research Institute CIBERESP, 20014 Donostia, Spain
- Konstantinos K. Tsilidis
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London SW7 2AZ, UK
- Elio Riboli
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London SW7 2AZ, UK
- Agnetha Linn Rostgaard-Hansen
- Danish Cancer Society Research Center, 2100 Copenhagen, Denmark
- Anne Tjønneland
- Danish Cancer Society Research Center, 2100 Copenhagen, Denmark
- Kim Overvad
- Department of Public Health, Section for Epidemiology, Aarhus University, 8000 Aarhus, Denmark
- Elisabete Weiderpass
- Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, 9019 Tromsø, Norway
- Marie-Christine Boutron-Ruault
- CESP “Health across Generations”, INSERM, Univ Paris-Sud, UVSQ, Univ Paris-Saclay, 94800 Villejuif, France
- Gianluca Severi
- CESP “Health across Generations”, INSERM, Univ Paris-Sud, UVSQ, Univ Paris-Saclay, 94800 Villejuif, France
- Antonia Trichopoulou
- Hellenic Health Foundation, 115 27 Athens, Greece
- Anna Karakatsani
- Hellenic Health Foundation, 115 27 Athens, Greece
- Anastasia Kotanidou
- Hellenic Health Foundation, 115 27 Athens, Greece
- Anders Håkansson
- Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Psychiatry, SE-221 00 Lund, Sweden
- Johan Malm
- Department of Translational Medicine, Clinical Chemistry, Lund University, Skåne University Hospital, 205 02 Malmö, Sweden
- Matty P. Weijenberg
- Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, 6229 HA Maastricht, The Netherlands
- Marc J. Gunter
- Nutritional Epidemiology Group, Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France
- Mazda Jenab
- Nutritional Epidemiology Group, Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France
- Mattias Johansson
- Genetic Epidemiology Group, Section of Genetics, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France
- Ruth C. Travis
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK
- Augustin Scalbert
- Biomarkers Group, Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France
- Pietro Ferrari
- Nutritional Methodology and Biostatistics Group, Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France
- DOI
- https://doi.org/10.3390/nu10050654
- Journal volume & issue
-
Vol. 10,
no. 5
p. 654
Abstract
Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTM p180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol consumption with metabolite concentrations. Metabolites significantly related to alcohol intake in the discovery set (FDR q-value < 0.05) were further tested in the replication set (Bonferroni-corrected p-value < 0.05). Of the 72 metabolites significantly related to alcohol intake in the discovery set, 34 were also significant in the replication analysis, including three acylcarnitines, the amino acid citrulline, four lysophosphatidylcholines, 13 diacylphosphatidylcholines, seven acyl-alkylphosphatidylcholines, and six sphingomyelins. Our results confirmed earlier findings that alcohol consumption was associated with several lipid metabolites, and possibly also with specific acylcarnitines and amino acids. This provides further leads for future research studies aiming at elucidating the mechanisms underlying the effects of alcohol in relation to morbid conditions.
Keywords