Romanian Journal of Laboratory Medicine (Dec 2015)
Pulmonary heart valve replacement using stabilized acellular xenogeneic scaffolds; effects of seeding with autologous stem cells
- Harpa Marius Mihai,
- Movileanu Ionela,
- Sierad Leslie Neil,
- Cotoi Ovidiu Simion,
- Suciu Horatiu,
- Sircuta Carmen,
- Preda Terezia,
- Nistor Dan,
- Branzaniuc Klara,
- Deac Radu,
- Dandel Michael,
- Gurzu Simona,
- Harceaga Lucian,
- Olah Peter,
- Simionescu Agneta,
- Simionescu Dan
Affiliations
- Harpa Marius Mihai
- 1. Tissue Engineering and Regenerative Medicine Laboratory, University of Medicine and Pharmacy, Targu Mures, Romania
- Movileanu Ionela
- 1. Tissue Engineering and Regenerative Medicine Laboratory, University of Medicine and Pharmacy, Targu Mures, Romania
- Sierad Leslie Neil
- 2. Aptus LLC, Clemson, SC, USA
- Cotoi Ovidiu Simion
- 1. Tissue Engineering and Regenerative Medicine Laboratory, University of Medicine and Pharmacy, Targu Mures, Romania
- Suciu Horatiu
- 3. Emergency Institute for Cardiovascular Diseases and Transplantation, Cardiovascular Surgery, Targu Mures, Romania
- Sircuta Carmen
- 3. Emergency Institute for Cardiovascular Diseases and Transplantation, Cardiovascular Surgery, Targu Mures, Romania
- Preda Terezia
- 1. Tissue Engineering and Regenerative Medicine Laboratory, University of Medicine and Pharmacy, Targu Mures, Romania
- Nistor Dan
- 3. Emergency Institute for Cardiovascular Diseases and Transplantation, Cardiovascular Surgery, Targu Mures, Romania
- Branzaniuc Klara
- 1. Tissue Engineering and Regenerative Medicine Laboratory, University of Medicine and Pharmacy, Targu Mures, Romania
- Deac Radu
- 1. Tissue Engineering and Regenerative Medicine Laboratory, University of Medicine and Pharmacy, Targu Mures, Romania
- Dandel Michael
- 1. Tissue Engineering and Regenerative Medicine Laboratory, University of Medicine and Pharmacy, Targu Mures, Romania
- Gurzu Simona
- 1. Tissue Engineering and Regenerative Medicine Laboratory, University of Medicine and Pharmacy, Targu Mures, Romania
- Harceaga Lucian
- 1. Tissue Engineering and Regenerative Medicine Laboratory, University of Medicine and Pharmacy, Targu Mures, Romania
- Olah Peter
- 1. Tissue Engineering and Regenerative Medicine Laboratory, University of Medicine and Pharmacy, Targu Mures, Romania
- Simionescu Agneta
- 4. Cardiovascular Tissue Engineering and Regenerative Medicine Laboratory, Clemson University, SC, USA
- Simionescu Dan
- 5. Clemson University Clemson, SC, USA
- DOI
- https://doi.org/10.1515/rrlm-2015-0046
- Journal volume & issue
-
Vol. 23,
no. 4
pp. 415 – 430
Abstract
Background: We hypothesized that an ideal heart valve replacement would be acellular valve root scaffolds seeded with autologous stem cells. To test this hypothesis, we prepared porcine acellular pulmonary valves, seeded them with autologous adipose derived stem cells (ADSCs) and implanted them in sheep and compared them to acellular valves.
Keywords
- scaffolds
- heart valves
- stem cells
- implantation
- animal model
- scaffolduri
- valve cardiace
- celule stem
- implantare
- model animal
