Nature Communications (Dec 2021)

Meta-analyses identify DNA methylation associated with kidney function and damage

  • Pascal Schlosser,
  • Adrienne Tin,
  • Pamela R. Matias-Garcia,
  • Chris H. L. Thio,
  • Roby Joehanes,
  • Hongbo Liu,
  • Antoine Weihs,
  • Zhi Yu,
  • Anselm Hoppmann,
  • Franziska Grundner-Culemann,
  • Josine L. Min,
  • Adebowale A. Adeyemo,
  • Charles Agyemang,
  • Johan Ärnlöv,
  • Nasir A. Aziz,
  • Andrea Baccarelli,
  • Murielle Bochud,
  • Hermann Brenner,
  • Monique M. B. Breteler,
  • Cristian Carmeli,
  • Layal Chaker,
  • John C. Chambers,
  • Shelley A. Cole,
  • Josef Coresh,
  • Tanguy Corre,
  • Adolfo Correa,
  • Simon R. Cox,
  • Niek de Klein,
  • Graciela E. Delgado,
  • Arce Domingo-Relloso,
  • Kai-Uwe Eckardt,
  • Arif B. Ekici,
  • Karlhans Endlich,
  • Kathryn L. Evans,
  • James S. Floyd,
  • Myriam Fornage,
  • Lude Franke,
  • Eliza Fraszczyk,
  • Xu Gao,
  • Xīn Gào,
  • Mohsen Ghanbari,
  • Sahar Ghasemi,
  • Christian Gieger,
  • Philip Greenland,
  • Megan L. Grove,
  • Sarah E. Harris,
  • Gibran Hemani,
  • Peter Henneman,
  • Christian Herder,
  • Steve Horvath,
  • Lifang Hou,
  • Mikko A. Hurme,
  • Shih-Jen Hwang,
  • Marjo-Riitta Jarvelin,
  • Sharon L. R. Kardia,
  • Silva Kasela,
  • Marcus E. Kleber,
  • Wolfgang Koenig,
  • Jaspal S. Kooner,
  • Holly Kramer,
  • Florian Kronenberg,
  • Brigitte Kühnel,
  • Terho Lehtimäki,
  • Lars Lind,
  • Dan Liu,
  • Yongmei Liu,
  • Donald M. Lloyd-Jones,
  • Kurt Lohman,
  • Stefan Lorkowski,
  • Ake T. Lu,
  • Riccardo E. Marioni,
  • Winfried März,
  • Daniel L. McCartney,
  • Karlijn A. C. Meeks,
  • Lili Milani,
  • Pashupati P. Mishra,
  • Matthias Nauck,
  • Ana Navas-Acien,
  • Christoph Nowak,
  • Annette Peters,
  • Holger Prokisch,
  • Bruce M. Psaty,
  • Olli T. Raitakari,
  • Scott M. Ratliff,
  • Alex P. Reiner,
  • Sylvia E. Rosas,
  • Ben Schöttker,
  • Joel Schwartz,
  • Sanaz Sedaghat,
  • Jennifer A. Smith,
  • Nona Sotoodehnia,
  • Hannah R. Stocker,
  • Silvia Stringhini,
  • Johan Sundström,
  • Brenton R. Swenson,
  • Maria Tellez-Plaza,
  • Joyce B. J. van Meurs,
  • Jana V. van Vliet-Ostaptchouk,
  • Andrea Venema,
  • Niek Verweij,
  • Rosie M. Walker,
  • Matthias Wielscher,
  • Juliane Winkelmann,
  • Bruce H. R. Wolffenbuttel,
  • Wei Zhao,
  • Yinan Zheng,
  • Estonian Biobank Research Team,
  • Genetics of DNA Methylation Consortium,
  • Marie Loh,
  • Harold Snieder,
  • Daniel Levy,
  • Melanie Waldenberger,
  • Katalin Susztak,
  • Anna Köttgen,
  • Alexander Teumer

DOI
https://doi.org/10.1038/s41467-021-27234-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

Read online

Many genetic loci have been identified to be associated with kidney disease, but the molecular mechanisms are not well understood. Here, the authors perform epigenome-wide association studies on kidney function measures to identify epigenetic marks and pathways involved in kidney function.