Nature Communications (Jun 2018)

Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment

  • Diego Scheggia,
  • Rosa Mastrogiacomo,
  • Maddalena Mereu,
  • Sara Sannino,
  • Richard E. Straub,
  • Marco Armando,
  • Francesca Managò,
  • Simone Guadagna,
  • Fabrizio Piras,
  • Fengyu Zhang,
  • Joel E. Kleinman,
  • Thomas M. Hyde,
  • Sanne S. Kaalund,
  • Maria Pontillo,
  • Genny Orso,
  • Carlo Caltagirone,
  • Emiliana Borrelli,
  • Maria A. De Luca,
  • Stefano Vicari,
  • Daniel R. Weinberger,
  • Gianfranco Spalletta,
  • Francesco Papaleo

DOI
https://doi.org/10.1038/s41467-018-04711-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

Read online

Patients with schizophrenia show varied response to antipsychotics. Here, the authors demonstrate in patients under antipsychotics treatment that a haplotype associated with lower dysbindin-1 expression correlated with better executive functions, providing further mechanistic support from mouse models.