Drug-Induced Autoimmune Hepatitis following Treatment with Zoledronic Acid

Abstract

Adverse drug reactions are among the most frequent side effects of synthetic and complementary alternative drugs and represent the premier causes of license revocations and acute liver failure. Drug-induced liver injury can resemble literally any other genuine liver disease and usually responds well to drug dechallenge. However, in some cases autoimmune-like hepatitis can evolve, requiring short- and sometimes long-term immunosuppression. Here, we present the hitherto first case of autoimmune-like hepatitis following treatment with zoledronic acid.

Keywords

• Acute hepatitis
• Drug-induced autoimmunity
• Immunosuppression
• Adverse hepatic drug reactions
• Drug-induced liver injury