Recent advances in managing systemic sclerosis [version 1; referees: 2 approved]

Abstract

How the main components in systemic sclerosis—namely autoimmunity, vasculopathy, and fibrosis—fit together is still not sufficiently clear. However, vascular treatment options are well established, the body of evidence for the efficacy of immunomodulatory approaches is increasing, and now at least one hopeful substance that may directly interfere with fibrosis is being tested. Although we still wait for important breakthroughs, there is grounds for hope that better therapeutic options will be available in the near future.

Keywords

• Autoimmunity
• Cardiovascular Pharmacology
• Cutaneous Signs of Systemic Disease
• Dermatologic Pharmacology
• Immune & Inflammatory Rheumatic Diseases (incl. Arthritis)
• Immunopharmacology & Hematologic Pharmacology
• Interstitial Lung Diseases
• Pulmonary Vascular Diseases
• Respiratory Pharmacology
• Urticaria, Vasculitis & Connective Tissue Disease
• Vascular Diseases (Non-Coronary)