Nature Communications (May 2020)
Functionally distinct high and low theta oscillations in the human hippocampus
- Abhinav Goyal,
- Jonathan Miller,
- Salman E. Qasim,
- Andrew J. Watrous,
- Honghui Zhang,
- Joel M. Stein,
- Cory S. Inman,
- Robert E. Gross,
- Jon T. Willie,
- Bradley Lega,
- Jui-Jui Lin,
- Ashwini Sharan,
- Chengyuan Wu,
- Michael R. Sperling,
- Sameer A. Sheth,
- Guy M. McKhann,
- Elliot H. Smith,
- Catherine Schevon,
- Joshua Jacobs
Affiliations
- Abhinav Goyal
- Mayo Clinic Medical Scientist Training Program, Mayo Clinic College of Medicine and Science, Mayo Clinic
- Jonathan Miller
- Department of Biomedical Engineering, Columbia University
- Salman E. Qasim
- Department of Biomedical Engineering, Columbia University
- Andrew J. Watrous
- Department of Neurology, University of Texas
- Honghui Zhang
- Department of Biomedical Engineering, Columbia University
- Joel M. Stein
- Department of Radiology, University of Pennsylvania
- Cory S. Inman
- Department of Neurosurgery, Emory University
- Robert E. Gross
- Department of Neurosurgery, Emory University
- Jon T. Willie
- Department of Neurosurgery, Emory University
- Bradley Lega
- Department of Neurological Surgery, University of Texas Southwestern
- Jui-Jui Lin
- Department of Neurological Surgery, University of Texas Southwestern
- Ashwini Sharan
- Department of Neurological Surgery, Thomas Jefferson University
- Chengyuan Wu
- Department of Neurological Surgery, Thomas Jefferson University
- Michael R. Sperling
- Jefferson Comprehensive Epilepsy Center, Thomas Jefferson University
- Sameer A. Sheth
- Department of Neurological Surgery, Baylor College of Medicine
- Guy M. McKhann
- Department of Neurosurgery, Columbia University Medical Center
- Elliot H. Smith
- Department of Neurosurgery, University of Utah
- Catherine Schevon
- Department of Neurology, Columbia University Medical Center
- Joshua Jacobs
- Department of Biomedical Engineering, Columbia University
- DOI
- https://doi.org/10.1038/s41467-020-15670-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 10
Abstract
We show that the human hippocampus exhibits two distinct theta oscillations during spatial navigation with the faster oscillation in posterior regions showing movement modulation. This result suggests a distinct feature of the human hippocampus compared to rodents, which generally show a single 8 Hz rhythm.
