Infection and Drug Resistance (May 2020)

Analysis of Urinary Pathogen Cultures and Drug Sensitivity in Patients with Urinary Stones for Five Consecutive Years in Xiangya Hospital, China

  • Bai Y,
  • Liu Q,
  • Gu J,
  • Zhang X,
  • Hu S

Journal volume & issue
Vol. Volume 13
pp. 1357 – 1363

Abstract

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Yao Bai,1,2 Qingxia Liu,3 Jie Gu,1,4 Xiaobo Zhang,1 Sheng Hu1 1Xiangya International Medical Center, Department of Geriatrics Urology, Xiangya Hospital, Central South University, Changsha 410008, People’s Republic of China; 2Medizinische Klinik and Poliklinik IV, Klinikum Der Universität München, Munich, Germany; 3Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha 410008, People’s Republic of China; 4Martini-Klinik Prostate Cancer Center, Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, GermanyCorrespondence: Xiaobo ZhangXiangya International Medical Center, Department of Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, People’s Republic of ChinaEmail [email protected] HuXiangya International Medical Center, Department of Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, People’s Republic of ChinaEmail [email protected]: To analyze pathogen distribution and drug sensitivity in patients with urinary calculi and thereby gain insight into the most appropriate antibacterial drugs for perioperative therapy.Materials and Methods: From January 2014 to December 2018, the results of mid-stream urine pathogen culture and drug sensitivity tests were evaluated retrospectively for 353 patients with urinary calculi. SPSS software version 23.0 was used to analyze the data.Results: A total of 353 strains of pathogens were isolated from urine culture. Among these, 278 (79%) strains belonged to the top 10 most frequently isolated pathogens, comprising 209 (75.2%) Gram-negative bacilli and 69 (24.8%) Gram-positive cocci. Escherichia coli was the most frequently isolated pathogen overall and the most frequently isolated Gram-negative bacillus, and Enterococcus faecalis was the most frequently isolated Gram-positive coccus. Drug sensitivity levels were effectively unchanged for less commonly used drugs, whereas drug resistance rates remained high for commonly used drugs such as ampicillin trihydrate, ampicillin/sulbactam, cefazolin, ceftriaxone, aztreonam, levofloxacin and ciprofloxacin.Conclusion: E. coli and E. faecalis remain the most common Gram-negative bacillus and Gram-positive coccus uropathogens, respectively, in patients with urinary calculi. Mid-stream urine pathogen culture and drug sensitivity tests should be used to select appropriate antibacterial drugs before treatment, particularly for perioperative patients with urinary calculi.Keywords: urine pathogen culture, drug sensitivity, urinary calculi, Escherichia coli, Enterococcus faecalis

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