Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target

Freek J. H. Sorgdrager; Freek J. H. Sorgdrager; Freek J. H. Sorgdrager; Freek J. H. Sorgdrager; Petrus J. W. Naudé; Petrus J. W. Naudé; Ido P. Kema; Ellen A. Nollen; Peter P. De Deyn; Peter P. De Deyn; Peter P. De Deyn

doi:10.3389/fimmu.2019.02565

Frontiers in Immunology (Oct 2019)

Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target

Freek J. H. Sorgdrager,
Freek J. H. Sorgdrager,
Freek J. H. Sorgdrager,
Freek J. H. Sorgdrager,
Petrus J. W. Naudé,
Petrus J. W. Naudé,
Ido P. Kema,
Ellen A. Nollen,
Peter P. De Deyn,
Peter P. De Deyn,
Peter P. De Deyn

Affiliations

Freek J. H. Sorgdrager: European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Freek J. H. Sorgdrager: Laboratory of Neurochemistry and Behavior, Department of Biomedical Sciences, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
Freek J. H. Sorgdrager: Department of Neurology and Alzheimer Center, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Freek J. H. Sorgdrager: Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Petrus J. W. Naudé: Department of Neurology and Alzheimer Center, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Petrus J. W. Naudé: Department of Molecular Neurobiology, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, Netherlands
Ido P. Kema: Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Ellen A. Nollen: European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Peter P. De Deyn: Laboratory of Neurochemistry and Behavior, Department of Biomedical Sciences, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
Peter P. De Deyn: Department of Neurology and Alzheimer Center, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Peter P. De Deyn: Department of Neurology, Memory Clinic of Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium

DOI: https://doi.org/10.3389/fimmu.2019.02565
Journal volume & issue: Vol. 10

Abstract

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Inflammation aims to restore tissue homeostasis after injury or infection. Age-related decline of tissue homeostasis causes a physiological low-grade chronic inflammatory phenotype known as inflammaging that is involved in many age-related diseases. Activation of tryptophan (Trp) metabolism along the kynurenine (Kyn) pathway prevents hyperinflammation and induces long-term immune tolerance. Systemic Trp and Kyn levels change upon aging and in age-related diseases. Moreover, modulation of Trp metabolism can either aggravate or prevent inflammaging-related diseases. In this review, we discuss how age-related Kyn/Trp activation is necessary to control inflammaging and alters the functioning of other metabolic faiths of Trp including Kyn metabolites, microbiota-derived indoles and nicotinamide adenine dinucleotide (NAD+). We explore the potential of the Kyn/Trp ratio as a biomarker of inflammaging and discuss how intervening in Trp metabolism might extend health- and lifespan.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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