Communications Biology (Jun 2022)

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

  • Thomas W. Winkler,
  • Humaira Rasheed,
  • Alexander Teumer,
  • Mathias Gorski,
  • Bryce X. Rowan,
  • Kira J. Stanzick,
  • Laurent F. Thomas,
  • Adrienne Tin,
  • Anselm Hoppmann,
  • Audrey Y. Chu,
  • Bamidele Tayo,
  • Chris H. L. Thio,
  • Daniele Cusi,
  • Jin-Fang Chai,
  • Karsten B. Sieber,
  • Katrin Horn,
  • Man Li,
  • Markus Scholz,
  • Massimiliano Cocca,
  • Matthias Wuttke,
  • Peter J. van der Most,
  • Qiong Yang,
  • Sahar Ghasemi,
  • Teresa Nutile,
  • Yong Li,
  • Giulia Pontali,
  • Felix Günther,
  • Abbas Dehghan,
  • Adolfo Correa,
  • Afshin Parsa,
  • Agnese Feresin,
  • Aiko P. J. de Vries,
  • Alan B. Zonderman,
  • Albert V. Smith,
  • Albertine J. Oldehinkel,
  • Alessandro De Grandi,
  • Alexander R. Rosenkranz,
  • Andre Franke,
  • Andrej Teren,
  • Andres Metspalu,
  • Andrew A. Hicks,
  • Andrew P. Morris,
  • Anke Tönjes,
  • Anna Morgan,
  • Anna I. Podgornaia,
  • Annette Peters,
  • Antje Körner,
  • Anubha Mahajan,
  • Archie Campbell,
  • Barry I. Freedman,
  • Beatrice Spedicati,
  • Belen Ponte,
  • Ben Schöttker,
  • Ben Brumpton,
  • Bernhard Banas,
  • Bernhard K. Krämer,
  • Bettina Jung,
  • Bjørn Olav Åsvold,
  • Blair H. Smith,
  • Boting Ning,
  • Brenda W. J. H. Penninx,
  • Brett R. Vanderwerff,
  • Bruce M. Psaty,
  • Candace M. Kammerer,
  • Carl D. Langefeld,
  • Caroline Hayward,
  • Cassandra N. Spracklen,
  • Cassianne Robinson-Cohen,
  • Catharina A. Hartman,
  • Cecilia M. Lindgren,
  • Chaolong Wang,
  • Charumathi Sabanayagam,
  • Chew-Kiat Heng,
  • Chiara Lanzani,
  • Chiea-Chuen Khor,
  • Ching-Yu Cheng,
  • Christian Fuchsberger,
  • Christian Gieger,
  • Christian M. Shaffer,
  • Christina-Alexandra Schulz,
  • Cristen J. Willer,
  • Daniel I. Chasman,
  • Daniel F. Gudbjartsson,
  • Daniela Ruggiero,
  • Daniela Toniolo,
  • Darina Czamara,
  • David J. Porteous,
  • Dawn M. Waterworth,
  • Deborah Mascalzoni,
  • Dennis O. Mook-Kanamori,
  • Dermot F. Reilly,
  • E. Warwick Daw,
  • Edith Hofer,
  • Eric Boerwinkle,
  • Erika Salvi,
  • Erwin P. Bottinger,
  • E-Shyong Tai,
  • Eulalia Catamo,
  • Federica Rizzi,
  • Feng Guo,
  • Fernando Rivadeneira,
  • Franco Guilianini,
  • Gardar Sveinbjornsson,
  • Georg Ehret,
  • Gerard Waeber,
  • Ginevra Biino,
  • Giorgia Girotto,
  • Giorgio Pistis,
  • Girish N. Nadkarni,
  • Graciela E. Delgado,
  • Grant W. Montgomery,
  • Harold Snieder,
  • Harry Campbell,
  • Harvey D. White,
  • He Gao,
  • Heather M. Stringham,
  • Helena Schmidt,
  • Hengtong Li,
  • Hermann Brenner,
  • Hilma Holm,
  • Holgen Kirsten,
  • Holly Kramer,
  • Igor Rudan,
  • Ilja M. Nolte,
  • Ioanna Tzoulaki,
  • Isleifur Olafsson,
  • Jade Martins,
  • James P. Cook,
  • James F. Wilson,
  • Jan Halbritter,
  • Janine F. Felix,
  • Jasmin Divers,
  • Jaspal S. Kooner,
  • Jeannette Jen-Mai Lee,
  • Jeffrey O’Connell,
  • Jerome I. Rotter,
  • Jianjun Liu,
  • Jie Xu,
  • Joachim Thiery,
  • Johan Ärnlöv,
  • Johanna Kuusisto,
  • Johanna Jakobsdottir,
  • Johanne Tremblay,
  • John C. Chambers,
  • John B. Whitfield,
  • John M. Gaziano,
  • Jonathan Marten,
  • Josef Coresh,
  • Jost B. Jonas,
  • Josyf C. Mychaleckyj,
  • Kaare Christensen,
  • Kai-Uwe Eckardt,
  • Karen L. Mohlke,
  • Karlhans Endlich,
  • Katalin Dittrich,
  • Kathleen A. Ryan,
  • Kenneth M. Rice,
  • Kent D. Taylor,
  • Kevin Ho,
  • Kjell Nikus,
  • Koichi Matsuda,
  • Konstantin Strauch,
  • Kozeta Miliku,
  • Kristian Hveem,
  • Lars Lind,
  • Lars Wallentin,
  • Laura M. Yerges-Armstrong,
  • Laura M. Raffield,
  • Lawrence S. Phillips,
  • Lenore J. Launer,
  • Leo-Pekka Lyytikäinen,
  • Leslie A. Lange,
  • Lorena Citterio,
  • Lucija Klaric,
  • M. Arfan Ikram,
  • Marcus Ising,
  • Marcus E. Kleber,
  • Margherita Francescatto,
  • Maria Pina Concas,
  • Marina Ciullo,
  • Mario Piratsu,
  • Marju Orho-Melander,
  • Markku Laakso,
  • Markus Loeffler,
  • Markus Perola,
  • Martin H. de Borst,
  • Martin Gögele,
  • Martina La Bianca,
  • Mary Ann Lukas,
  • Mary F. Feitosa,
  • Mary L. Biggs,
  • Mary K. Wojczynski,
  • Maryam Kavousi,
  • Masahiro Kanai,
  • Masato Akiyama,
  • Masayuki Yasuda,
  • Matthias Nauck,
  • Melanie Waldenberger,
  • Miao-Li Chee,
  • Miao-Ling Chee,
  • Michael Boehnke,
  • Michael H. Preuss,
  • Michael Stumvoll,
  • Michael A. Province,
  • Michele K. Evans,
  • Michelle L. O’Donoghue,
  • Michiaki Kubo,
  • Mika Kähönen,
  • Mika Kastarinen,
  • Mike A. Nalls,
  • Mikko Kuokkanen,
  • Mohsen Ghanbari,
  • Murielle Bochud,
  • Navya Shilpa Josyula,
  • Nicholas G. Martin,
  • Nicholas Y. Q. Tan,
  • Nicholette D. Palmer,
  • Nicola Pirastu,
  • Nicole Schupf,
  • Niek Verweij,
  • Nina Hutri-Kähönen,
  • Nina Mononen,
  • Nisha Bansal,
  • Olivier Devuyst,
  • Olle Melander,
  • Olli T. Raitakari,
  • Ozren Polasek,
  • Paolo Manunta,
  • Paolo Gasparini,
  • Pashupati P. Mishra,
  • Patrick Sulem,
  • Patrik K. E. Magnusson,
  • Paul Elliott,
  • Paul M. Ridker,
  • Pavel Hamet,
  • Per O. Svensson,
  • Peter K. Joshi,
  • Peter Kovacs,
  • Peter P. Pramstaller,
  • Peter Rossing,
  • Peter Vollenweider,
  • Pim van der Harst,
  • Rajkumar Dorajoo,
  • Ralene Z. H. Sim,
  • Ralph Burkhardt,
  • Ran Tao,
  • Raymond Noordam,
  • Reedik Mägi,
  • Reinhold Schmidt,
  • Renée de Mutsert,
  • Rico Rueedi,
  • Rob M. van Dam,
  • Robert J. Carroll,
  • Ron T. Gansevoort,
  • Ruth J. F. Loos,
  • Sala Cinzia Felicita,
  • Sanaz Sedaghat,
  • Sandosh Padmanabhan,
  • Sandra Freitag-Wolf,
  • Sarah A. Pendergrass,
  • Sarah E. Graham,
  • Scott D. Gordon,
  • Shih-Jen Hwang,
  • Shona M. Kerr,
  • Simona Vaccargiu,
  • Snehal B. Patil,
  • Stein Hallan,
  • Stephan J. L. Bakker,
  • Su-Chi Lim,
  • Susanne Lucae,
  • Suzanne Vogelezang,
  • Sven Bergmann,
  • Tanguy Corre,
  • Tarunveer S. Ahluwalia,
  • Terho Lehtimäki,
  • Thibaud S. Boutin,
  • Thomas Meitinger,
  • Tien-Yin Wong,
  • Tobias Bergler,
  • Ton J. Rabelink,
  • Tõnu Esko,
  • Toomas Haller,
  • Unnur Thorsteinsdottir,
  • Uwe Völker,
  • Valencia Hui Xian Foo,
  • Veikko Salomaa,
  • Veronique Vitart,
  • Vilmantas Giedraitis,
  • Vilmundur Gudnason,
  • Vincent W. V. Jaddoe,
  • Wei Huang,
  • Weihua Zhang,
  • Wen Bin Wei,
  • Wieland Kiess,
  • Winfried März,
  • Wolfgang Koenig,
  • Wolfgang Lieb,
  • Xin Gao,
  • Xueling Sim,
  • Ya Xing Wang,
  • Yechiel Friedlander,
  • Yih-Chung Tham,
  • Yoichiro Kamatani,
  • Yukinori Okada,
  • Yuri Milaneschi,
  • Zhi Yu,
  • Lifelines cohort study,
  • DiscovEHR/MyCode study,
  • VA Million Veteran Program,
  • Klaus J. Stark,
  • Kari Stefansson,
  • Carsten A. Böger,
  • Adriana M. Hung,
  • Florian Kronenberg,
  • Anna Köttgen,
  • Cristian Pattaro,
  • Iris M. Heid

DOI
https://doi.org/10.1038/s42003-022-03448-z
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 20

Abstract

Read online

A large-scale GWAS provides insight on diabetes-dependent genetic effects on the glomerular filtration rate, a common metric to monitor kidney health in disease.