Nature Communications (Nov 2022)
DNA methylation-based classification of sinonasal tumors
- Philipp Jurmeister,
- Stefanie Glöß,
- Renée Roller,
- Maximilian Leitheiser,
- Simone Schmid,
- Liliana H. Mochmann,
- Emma Payá Capilla,
- Rebecca Fritz,
- Carsten Dittmayer,
- Corinna Friedrich,
- Anne Thieme,
- Philipp Keyl,
- Armin Jarosch,
- Simon Schallenberg,
- Hendrik Bläker,
- Inga Hoffmann,
- Claudia Vollbrecht,
- Annika Lehmann,
- Michael Hummel,
- Daniel Heim,
- Mohamed Haji,
- Patrick Harter,
- Benjamin Englert,
- Stephan Frank,
- Jürgen Hench,
- Werner Paulus,
- Martin Hasselblatt,
- Wolfgang Hartmann,
- Hildegard Dohmen,
- Ursula Keber,
- Paul Jank,
- Carsten Denkert,
- Christine Stadelmann,
- Felix Bremmer,
- Annika Richter,
- Annika Wefers,
- Julika Ribbat-Idel,
- Sven Perner,
- Christian Idel,
- Lorenzo Chiariotti,
- Rosa Della Monica,
- Alfredo Marinelli,
- Ulrich Schüller,
- Michael Bockmayr,
- Jacklyn Liu,
- Valerie J. Lund,
- Martin Forster,
- Matt Lechner,
- Sara L. Lorenzo-Guerra,
- Mario Hermsen,
- Pascal D. Johann,
- Abbas Agaimy,
- Philipp Seegerer,
- Arend Koch,
- Frank Heppner,
- Stefan M. Pfister,
- David T. W. Jones,
- Martin Sill,
- Andreas von Deimling,
- Matija Snuderl,
- Klaus-Robert Müller,
- Erna Forgó,
- Brooke E. Howitt,
- Philipp Mertins,
- Frederick Klauschen,
- David Capper
Affiliations
- Philipp Jurmeister
- Institute of Pathology, Ludwig Maximilians University Hospital Munich
- Stefanie Glöß
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology
- Renée Roller
- Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Maximilian Leitheiser
- Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Simone Schmid
- German Cancer Consortium (DKTK), Partner Site Berlin, and German Cancer Research Center (DKFZ)
- Liliana H. Mochmann
- Institute of Pathology, Ludwig Maximilians University Hospital Munich
- Emma Payá Capilla
- Institute of Pathology, Ludwig Maximilians University Hospital Munich
- Rebecca Fritz
- Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Carsten Dittmayer
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology
- Corinna Friedrich
- Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Anne Thieme
- German Cancer Consortium (DKTK), Partner Site Berlin, and German Cancer Research Center (DKFZ)
- Philipp Keyl
- Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Armin Jarosch
- Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Simon Schallenberg
- Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Hendrik Bläker
- Institute of Pathology, University Hospital Leipzig
- Inga Hoffmann
- Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Claudia Vollbrecht
- Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Annika Lehmann
- Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Michael Hummel
- Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Daniel Heim
- Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Mohamed Haji
- Proteomics Platform, Berlin Institute of Health (BIH) and Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
- Patrick Harter
- German Cancer Consortium (DKTK), Partner Site Munich, and German Cancer Research Center (DKFZ)
- Benjamin Englert
- Institute of Neuropathology, Ludwig Maximilians University Hospital Munich
- Stephan Frank
- Department of Neuropathology, Institute of Pathology, Basel University Hospital
- Jürgen Hench
- Department of Neuropathology, Institute of Pathology, Basel University Hospital
- Werner Paulus
- Institute of Neuropathology, University Hospital Münster
- Martin Hasselblatt
- Institute of Neuropathology, University Hospital Münster
- Wolfgang Hartmann
- Division of Translational Pathology, Gerhard-Domagk-Institute of Pathology, University Hospital Münster
- Hildegard Dohmen
- Institute of Neuropathology, University of Giessen
- Ursula Keber
- Institute of Neuropathology, Philipps-University
- Paul Jank
- Institute of Pathology, Philipps-University Marburg and University Hospital Marburg
- Carsten Denkert
- Institute of Pathology, Philipps-University Marburg and University Hospital Marburg
- Christine Stadelmann
- Institute for Neuropathology, University Medical Centre Göttingen
- Felix Bremmer
- Institute of Pathology, University Medical Center
- Annika Richter
- Institute of Pathology, University Medical Center
- Annika Wefers
- Department of Neuropathology, University Hospital Heidelberg
- Julika Ribbat-Idel
- Institute of Pathology, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck
- Sven Perner
- Institute of Pathology, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck
- Christian Idel
- Department of Otorhinolaryngology, University Hospital Schleswig-Holstein, Campus Lübeck
- Lorenzo Chiariotti
- Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II
- Rosa Della Monica
- CEINGE Biotecnologie Avanzate
- Alfredo Marinelli
- Department of Medicina Clinica e Chirurgia, University Federico II
- Ulrich Schüller
- Institute of Neuropathology, University Medical Center Hamburg-Eppendorf
- Michael Bockmayr
- Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Jacklyn Liu
- UCL Cancer Institute, University College London
- Valerie J. Lund
- UCL Cancer Institute, University College London
- Martin Forster
- UCL Cancer Institute, University College London
- Matt Lechner
- UCL Cancer Institute, University College London
- Sara L. Lorenzo-Guerra
- Department of Head and Neck Oncology, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)
- Mario Hermsen
- Department of Head and Neck Oncology, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)
- Pascal D. Johann
- Swabian Childrens’ Cancer Center, University Childrens’ Hospital Augsburg and EU-RHAB Registry
- Abbas Agaimy
- Institute of Pathology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital
- Philipp Seegerer
- Machine-Learning Group, Department of Software Engineering and Theoretical Computer Science, Technical University of Berlin
- Arend Koch
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology
- Frank Heppner
- German Cancer Consortium (DKTK), Partner Site Berlin, and German Cancer Research Center (DKFZ)
- Stefan M. Pfister
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- David T. W. Jones
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Martin Sill
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Andreas von Deimling
- Department of Neuropathology, University Hospital Heidelberg
- Matija Snuderl
- Division of Neuropathology, NYU Langone Health
- Klaus-Robert Müller
- Machine-Learning Group, Department of Software Engineering and Theoretical Computer Science, Technical University of Berlin
- Erna Forgó
- Stanford University School of Medicine
- Brooke E. Howitt
- Stanford University School of Medicine
- Philipp Mertins
- Proteomics Platform, Berlin Institute of Health (BIH) and Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
- Frederick Klauschen
- Institute of Pathology, Ludwig Maximilians University Hospital Munich
- David Capper
- German Cancer Consortium (DKTK), Partner Site Berlin, and German Cancer Research Center (DKFZ)
- DOI
- https://doi.org/10.1038/s41467-022-34815-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Sinonasal tumour diagnosis can be complicated by the heterogeneity of disease and classification systems. Here, the authors use machine learning to classify sinonasal undifferentiated carcinomas into 4 molecular classe with differences in differentiation state and clinical outcome.
