Cancer Management and Research (Feb 2020)

Comparison of chemoembolization with CalliSpheres® microspheres and conventional chemoembolization in the treatment of hepatocellular carcinoma: a multicenter retrospective study

  • Liang B,
  • Xiang H,
  • Ma C,
  • Xiong B,
  • Ma Y,
  • Zhao C,
  • Yao Y,
  • Zhang Z,
  • Chen C,
  • Li H,
  • Long Q,
  • Zhou J,
  • Luo C,
  • Qiu H,
  • Hu H,
  • Zhao H,
  • Zhou G,
  • Zheng C

Journal volume & issue
Vol. Volume 12
pp. 941 – 956

Abstract

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Bin Liang, 1,* Hua Xiang, 2,* Cong Ma, 3 Bin Xiong, 1 Yilong Ma, 4 Chang Zhao, 4 Yuanhui Yao, 2 Zishu Zhang, 3 Changyong Chen, 5 Haiping Li, 5 Qingyun Long, 6 Jun Zhou, 6 Chao Luo, 7 Huaiming Qiu, 7 Hongyao Hu, 8 Hui Zhao, 8 Guofeng Zhou, 1 Chuansheng Zheng 1 1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Department of Interventional Radiology, Hunan Provincial People’s Hospital, Changsha, People’s Republic of China; 3Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, People’s Republic of China; 4Department of Interventional Radiology, Cancer Hospital Affiliated to Guangxi Medical University, Nanning, People’s Republic of China; 5Department of Radiology, Xiangya Hospital General South University, Changsha, People’s Republic of China; 6Department of Interventional Radiology, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 7Department of Radiology, Wuhan General Hospital of Guangzhou Military Region, Wuhan, People’s Republic of China; 8Department of Interventional Radiology, Renmin Hospital of Wuhan University, Hubei General Hospital, Wuhan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chuansheng ZhengDepartment of Radiology, Hubei Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan 430022, People’s Republic of ChinaEmail [email protected] Guofeng ZhouDepartment of Radiology, Hubei Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People’s Republic of ChinaEmail [email protected]: This study aimed to compare the efficacy and safety between transarterial chemoembolization (TACE) with CalliSpheres® microspheres (CSM-TACE) and conventional TACE (cTACE) in patients with hepatocellular carcinoma (HCC).Patients and Methods: Three hundred and thirty-five HCC patients receiving CSM-TACE or cTACE were consecutively enrolled in this multi-center, retrospective cohort study, and then divided into CSM-TACE group and cTACE group accordingly. Complete response (CR), objective response (ORR) and disease control response (DCR) was assessed according to mRECIST criteria at 1 month (M1), 3 months(M3) and 6 months(M6) after treatment. Progression-free survival (PFS) and overall survival (OS) were assessed. Liver function indexes and adverse events (AEs) were also evaluated.Results: CR at M3 (P=0.020) and ORR at M1 (P< 0.001), M3 (P< 0.001) and M6 (P=0.017) after treatment were significantly higher in the CSM-TACE compared with cTACE group. DCRs, PFS (25.3 months vs 24.2 months, P=0.503) and OS (27.8 months vs 25.3 months, P=0.203) were similar between the two groups. CSM-TACE was independently correlated with higher ORR at M1 (P=0.002) and longer OS (P=0.023). Abnormal alkaline phosphatase (ALP) (P=0.049) was independently associated with lower ORR at M3, and history of alcohol intake (P=0.019) and largest nodule size ≥ 7 cm (P=0.015) independently correlated with lower ORR at M6 (P=0.015). Largest nodule size ≥ 7 cm (P=0.029) and abnormal albumin (ALB) (P=0.046) were independently associated with shorter PFS. Child-Pugh stage B/C (P=0.023), abnormal ALB (P=0.001), ALP (P=0.008) and alpha-fetoprotein (AFP) (P=0.005) were independently associated with shorter OS. Most liver function indexes and AEs were similar between the two groups (P> 0.05), except that ALP (P=0.005), total bilirubin (P=0.031), pain during procedure (P=0.034) and occurrence of fever post(treatment (P=0.017) were significantly elevated in the CSM-TACE compared with cTACE group.Conclusion: CSM-TACE presents with a better treatment response and similar survival profile compared with cTACE in HCC patients.Keywords: chemoembolization, CalliSpheres microspheres, hepatocellular carcinoma, treatment response, survival, predictive factor

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