Nutrients (Jun 2019)
Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study)
- Mireia Obón-Santacana,
- Dora Romaguera,
- Esther Gracia-Lavedan,
- Amaia Molinuevo,
- Esther Molina-Montes,
- Nitin Shivappa,
- James R. Hebert,
- Adonina Tardón,
- Gemma Castaño-Vinyals,
- Ferran Moratalla,
- Elisabet Guinó,
- Rafael Marcos-Gragera,
- Mikel Azpiri,
- Leire Gil,
- Rocío Olmedo-Requena,
- Macarena Lozano-Lorca,
- Juan Alguacil,
- Tania Fernández-Villa,
- Vicente Martín,
- Antonio J Molina,
- María Ederra,
- Conchi Moreno-Iribas,
- Beatriz Perez,
- Nuria Aragonés,
- Adela Castello,
- José Mª Huerta,
- Trinidad Dierssen-Sotos,
- Inés Gómez-Acebo,
- Ana Molina-Barceló,
- Marina Pollán,
- Manolis Kogevinas,
- Victor Moreno,
- Pilar Amiano
Affiliations
- Mireia Obón-Santacana
- Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L’Hospitalet del Llobregat, 08908 Barcelona, Spain
- Dora Romaguera
- Instituto de Salud Global de Barcelona (ISGlobal), 08036 Barcelona, Spain
- Esther Gracia-Lavedan
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Amaia Molinuevo
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Esther Molina-Montes
- Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), 28029 Madrid, Spain
- Nitin Shivappa
- Cancer Prevention and Control Program, University of South Carolina, Columbia, SC 29208, USA.
- James R. Hebert
- Cancer Prevention and Control Program, University of South Carolina, Columbia, SC 29208, USA.
- Adonina Tardón
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Gemma Castaño-Vinyals
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Ferran Moratalla
- Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L’Hospitalet del Llobregat, 08908 Barcelona, Spain
- Elisabet Guinó
- Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L’Hospitalet del Llobregat, 08908 Barcelona, Spain
- Rafael Marcos-Gragera
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Mikel Azpiri
- Public Health Division of Gipuzkoa, 20003 San Sebastian, Spain
- Leire Gil
- Public Health Division of Gipuzkoa, 20003 San Sebastian, Spain
- Rocío Olmedo-Requena
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Macarena Lozano-Lorca
- Department of Preventive Medicine and Public Health, School of Medicine, University of Granada, 18016 Granada, Spain
- Juan Alguacil
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Tania Fernández-Villa
- The Research Group in Gene - Environment and Health Interactions (GIIGAS) / Institut of Biomedicine (IBIOMED), Universidad de León, 24071 León, Spain
- Vicente Martín
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Antonio J Molina
- The Research Group in Gene - Environment and Health Interactions (GIIGAS) / Institut of Biomedicine (IBIOMED), Universidad de León, 24071 León, Spain
- María Ederra
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Conchi Moreno-Iribas
- Navarra Public Health Institute, 31003 Pamplona, Spain
- Beatriz Perez
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Nuria Aragonés
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Adela Castello
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- José Mª Huerta
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Trinidad Dierssen-Sotos
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Inés Gómez-Acebo
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Ana Molina-Barceló
- Cancer and Public Health Area, FISABIO—Public Health; 46020 Valencia, Spain
- Marina Pollán
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Manolis Kogevinas
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Victor Moreno
- Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L’Hospitalet del Llobregat, 08908 Barcelona, Spain
- Pilar Amiano
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- DOI
- https://doi.org/10.3390/nu11061406
- Journal volume & issue
-
Vol. 11,
no. 6
p. 1406
Abstract
Inflammation and antioxidant capacity have been associated with colorectal and breast cancer. We computed the dietary inflammatory index (DII®), and the total dietary non-enzymatic antioxidant capacity (NEAC) and associated them with colorectal and breast cancer risk in the population-based multi case-control study in Spain (MCC-Spain). We included 1852 colorectal cancer and 1567 breast cancer cases, and 3447 and 1486 population controls, respectively. DII score and NEAC were derived using data from a semi-quantitative validated food frequency questionnaire. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for energy-adjusted DII (E-DII), and a score combining E-DII and NEAC. E-DII was associated with colorectal cancer risk (OR = 1.93, highest quartile versus lowest, 95%CI:1.60−2.32; p-trend: <0.001); this increase was observed for both colon and rectal cancer. Less pronounced increased risks were observed for breast cancer (OR = 1.22, highest quartile versus lowest, 95%CI:0.99−1.52, p-trend: >0.10). The combined score of high E-DII scores and low antioxidant values were associated with colorectal cancer risk (OR = 1.48, highest quartile versus lowest, 95%CI: 1.26−1.74; p-trend: <0.001), but not breast cancer. This study provides evidence that a pro-inflammatory diet is associated with increased colorectal cancer risk while findings for breast cancer were less consistent.
Keywords
- colorectal cancer
- breast cancer
- diet
- dietary inflammatory index
- antioxidants
- NEAC
- case-control study
- MCC-Spain