Nature Communications (Feb 2018)
A transcriptomic atlas of aged human microglia
- Marta Olah,
- Ellis Patrick,
- Alexandra-Chloe Villani,
- Jishu Xu,
- Charles C. White,
- Katie J. Ryan,
- Paul Piehowski,
- Alifiya Kapasi,
- Parham Nejad,
- Maria Cimpean,
- Sarah Connor,
- Christina J. Yung,
- Michael Frangieh,
- Allison McHenry,
- Wassim Elyaman,
- Vlad Petyuk,
- Julie A. Schneider,
- David A. Bennett,
- Philip L. De Jager,
- Elizabeth M. Bradshaw
Affiliations
- Marta Olah
- Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center
- Ellis Patrick
- School of Mathematics and Statistics, The University of Sydney
- Alexandra-Chloe Villani
- Program in Medical and Population Genetics, Broad Institute
- Jishu Xu
- Program in Medical and Population Genetics, Broad Institute
- Charles C. White
- Program in Medical and Population Genetics, Broad Institute
- Katie J. Ryan
- Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
- Paul Piehowski
- Pacific Northwest National Laboratory
- Alifiya Kapasi
- Pacific Northwest National Laboratory
- Parham Nejad
- Program in Medical and Population Genetics, Broad Institute
- Maria Cimpean
- Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
- Sarah Connor
- Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center
- Christina J. Yung
- Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center
- Michael Frangieh
- Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
- Allison McHenry
- Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
- Wassim Elyaman
- Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center
- Vlad Petyuk
- Pacific Northwest National Laboratory
- Julie A. Schneider
- Rush Alzheimer’s Disease Center, Rush University Medical Center
- David A. Bennett
- Rush Alzheimer’s Disease Center, Rush University Medical Center
- Philip L. De Jager
- Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center
- Elizabeth M. Bradshaw
- Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center
- DOI
- https://doi.org/10.1038/s41467-018-02926-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 8
Abstract
Aging is associated with various changes in the brain, including transcription alteration. Here, Bradshaw and colleagues describe the transcriptome of aged human cortical microglia, and show age-related gene expression as related to neurodegeneration.
