Journal of Inflammation Research (Jul 2022)

The Emerging Role of Immune Cells and Targeted Therapeutic Strategies in Diabetic Wounds Healing

  • Song J,
  • Hu L,
  • Liu B,
  • Jiang N,
  • Huang H,
  • Luo J,
  • Wang L,
  • Zeng J,
  • Huang F,
  • Huang M,
  • Cai L,
  • Tang L,
  • Chen S,
  • Chen Y,
  • Wu A,
  • Zheng S,
  • Chen Q

Journal volume & issue
Vol. Volume 15
pp. 4119 – 4138

Abstract

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Jianying Song,1,2,* Lixin Hu,1,2,* Bo Liu,2 Nan Jiang,3 Houqiang Huang,4 JieSi Luo,3 Long Wang,3 Jing Zeng,3 Feihong Huang,3 Min Huang,5 Luyao Cai,2 Lingyu Tang,2 Shunli Chen,2 Yinyi Chen,2 Anguo Wu,3 Silin Zheng,4 Qi Chen1,2,6,7 1Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China; 2School of Nursing, Southwest Medical University, Luzhou, People’s Republic of China; 3Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, People’s Republic of China; 4Department of Nursing, the Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China; 5Department of Respiratory and Critical Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China; 6Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, People’s Republic of China; 7Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qi Chen, Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China, Tel +0086-18383008873, Email [email protected] Silin Zheng, Department of Nursing, the Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China, Tel +86-13002866667, Email [email protected]: Poor wound healing in individuals with diabetes has long plagued clinicians, and immune cells play key roles in the inflammation, proliferation and remodeling that occur in wound healing. When skin integrity is damaged, immune cells migrate to the wound bed through the actions of chemokines and jointly restore tissue homeostasis and barrier function by exerting their respective biological functions. An imbalance of immune cells often leads to ineffective and disordered inflammatory responses. Due to the maladjusted microenvironment, the wound is unable to smoothly transition to the proliferation and remodeling stage, causing it to develop into a chronic refractory wound. However, chronic refractory wounds consistently lead to negative outcomes, such as long treatment cycles, high hospitalization rates, high medical costs, high disability rates, high mortality rates, and many adverse consequences. Therefore, strategies that promote the rational distribution and coordinated development of immune cells during wound healing are very important for the treatment of diabetic wounds (DW). Here, we explored the following aspects by performing a literature review: 1) the current situation of DW and an introduction to the biological functions of immune cells; 2) the role of immune cells in DW; and 3) existing (or undeveloped) therapies targeting immune cells to promote wound healing to provide new ideas for basic research, clinical treatment and nursing of DW.Keywords: diabetic wounds, wound healing, immune cells, inflammation, targeted therapy

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