Beilstein Journal of Organic Chemistry (Jan 2020)
Rapid, two-pot procedure for the synthesis of dihydropyridinones; total synthesis of aza-goniothalamin
Abstract
A fast, protecting-group-free synthesis of dihydropyridinones has been developed. Starting from commercially available aldehydes, a novel one-pot amidoallylation gave access to diene compounds in good yields. Ring-closing metathesis conditions were then employed to produce the target dihydropyridinones efficiently and in high yields.
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