Infection and Drug Resistance (Oct 2022)
Age-Dependent Clinical Characteristics of Acute Lower Respiratory Infections in Young Hospitalized Children with Respiratory Syncytial Virus Infection
Abstract
Li Li,1 Heping Wang,1 Ailiang Liu,1 Jiehua Chen,1 Yonghong Yang,1,2 Wenjian Wang1 1Department of Respiratory Diseases, Shenzhen Children’s Hospital, Shenzhen, People’s Republic of China; 2Microbiology Laboratory, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, People’s Republic of ChinaCorrespondence: Yonghong Yang, Microbiology Laboratory, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, People’s Republic of China, Email [email protected] Wenjian Wang, Department of Respiratory Diseases, Shenzhen Children’s Hospital, No. 7019 Yitian Road, Futian District, Shenzhen, Guangdong, People’s Republic of China, Email [email protected]: Human respiratory syncytial virus (HRSV) is the most common cause of acute lower respiratory infection (LRTI) in children. The main clinical manifestations are fever, cough, wheezing, and intercostal retractions. Its age-dependent clinical characteristics remain to be defined.Objective: We investigated whether HRSV caused any age-related differences in clinical manifestations of LRTI.Methods: We enrolled 130 hospitalized children with LRTI caused by HRSV. These were stratified into four age groups. The main signs and symptoms and rates thereof were compared across the four age groups.Results: The incidence of pneumonia was the same in all four age groups. Patients in the 1– 6 months old group experienced fever and the highest body temperature ≥ 38.5°C less frequently than patients in other age groups.The frequency of fever increased with age among the patients under 24 months old. Children over 12 months old experienced less wheezing, tachypnoea, hypoxia, and intercostal retractions than children in the 1– 6 months old group.Conclusion: HRSV caused age-related differences in clinical manifestations of LRTI. Reduced fever responses among patients 6 months old and younger during RSV infection does not implicate less severity, wheezing, tachypnoea, hypoxia, and intercostal retractions are the main clinical manifestations, Fever responses were enhanced with advancing age among children under 24 months old.Keywords: human respiratory syncytial virus, lower respiratory infections, clinical manifestation, hospitalized children
