Nature Communications (Dec 2016)
Evolution of multiple cell clones over a 29-year period of a CLL patient
- Zhikun Zhao,
- Lynn Goldin,
- Shiping Liu,
- Liang Wu,
- Weiyin Zhou,
- Hong Lou,
- Qichao Yu,
- Shirley X. Tsang,
- Miaomiao Jiang,
- Fuqiang Li,
- MaryLou McMaster,
- Yang Li,
- Xinxin Lin,
- Zhifeng Wang,
- Liqin Xu,
- Gerald Marti,
- Guibo Li,
- Kui Wu,
- Meredith Yeager,
- Huanming Yang,
- Xun Xu,
- Stephen J. Chanock,
- Bo Li,
- Yong Hou,
- Neil Caporaso,
- Michael Dean
Affiliations
- Zhikun Zhao
- BGI-Shenzhen
- Lynn Goldin
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Shiping Liu
- BGI-Shenzhen
- Liang Wu
- BGI-Shenzhen
- Weiyin Zhou
- Division of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Leidos Biomedical Research Inc.
- Hong Lou
- Division of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Leidos Biomedical Research Inc.
- Qichao Yu
- BGI-Shenzhen
- Shirley X. Tsang
- Biomatrix
- Miaomiao Jiang
- BGI-Shenzhen
- Fuqiang Li
- BGI-Shenzhen
- MaryLou McMaster
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Yang Li
- BGI-Shenzhen
- Xinxin Lin
- BGI-Shenzhen
- Zhifeng Wang
- BGI-Shenzhen
- Liqin Xu
- BGI-Shenzhen
- Gerald Marti
- Center for Devices and Radiological Health, Food and Drug Administration
- Guibo Li
- BGI-Shenzhen
- Kui Wu
- BGI-Shenzhen
- Meredith Yeager
- Division of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Leidos Biomedical Research Inc.
- Huanming Yang
- BGI-Shenzhen
- Xun Xu
- BGI-Shenzhen
- Stephen J. Chanock
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Bo Li
- BGI-Shenzhen
- Yong Hou
- BGI-Shenzhen
- Neil Caporaso
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Michael Dean
- BGI-Shenzhen
- DOI
- https://doi.org/10.1038/ncomms13765
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
Studying the genetic progression of many cancers is difficult as longitudinal samples are rarely available. Here, the authors analyse a patient with chronic lymphocytic leukaemia over a 29 year period and track the clonal evolution of the patient’s disease and response to therapy.
