Nature Communications (Aug 2021)
Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth
- Todd M. Everson,
- Marta Vives-Usano,
- Emie Seyve,
- Andres Cardenas,
- Marina Lacasaña,
- Jeffrey M. Craig,
- Corina Lesseur,
- Emily R. Baker,
- Nora Fernandez-Jimenez,
- Barbara Heude,
- Patrice Perron,
- Beatriz Gónzalez-Alzaga,
- Jane Halliday,
- Maya A. Deyssenroth,
- Margaret R. Karagas,
- Carmen Íñiguez,
- Luigi Bouchard,
- Pedro Carmona-Sáez,
- Yuk J. Loke,
- Ke Hao,
- Thalia Belmonte,
- Marie A. Charles,
- Jordi Martorell-Marugán,
- Evelyne Muggli,
- Jia Chen,
- Mariana F. Fernández,
- Jorg Tost,
- Antonio Gómez-Martín,
- Stephanie J. London,
- Jordi Sunyer,
- Carmen J. Marsit,
- Johanna Lepeule,
- Marie-France Hivert,
- Mariona Bustamante
Affiliations
- Todd M. Everson
- Gangarosa Department of Environmental Health, Rollins School of Public Health at Emory University
- Marta Vives-Usano
- Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology
- Emie Seyve
- University Grenoble Alpes, Inserm, CNRS, IAB
- Andres Cardenas
- Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute
- Marina Lacasaña
- CIBER Epidemiología y Salud Pública (CIBERESP)
- Jeffrey M. Craig
- Epigenetics Group, Murdoch Children’s Research Institute
- Corina Lesseur
- Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai
- Emily R. Baker
- Department of Obstetrics & Gynecology, Geisel School of Medicine at Dartmouth College
- Nora Fernandez-Jimenez
- University of the Basque Country (UPV/EHU)
- Barbara Heude
- Université de Paris, CRESS, INSERM, INRAE
- Patrice Perron
- Department of Medicine, University of Sherbrooke
- Beatriz Gónzalez-Alzaga
- Andalusian School of Public Health
- Jane Halliday
- Department of Paediatrics, University of Melbourne
- Maya A. Deyssenroth
- Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai
- Margaret R. Karagas
- Department of Epidemiology, Geisel School of Medicine at Dartmouth College
- Carmen Íñiguez
- CIBER Epidemiología y Salud Pública (CIBERESP)
- Luigi Bouchard
- Department of Biochemistry and Functional Genomics, University of Sherbrooke
- Pedro Carmona-Sáez
- Bioinformatics Unit, GENYO. Centre for Genomics and Oncological Research, Pfizer, University of Granada, Andalusian Regional Government
- Yuk J. Loke
- Epigenetics Group, Murdoch Children’s Research Institute
- Ke Hao
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Thalia Belmonte
- IUOPA University of Oviedo
- Marie A. Charles
- Université de Paris, CRESS, INSERM, INRAE
- Jordi Martorell-Marugán
- Bioinformatics Unit, GENYO. Centre for Genomics and Oncological Research, Pfizer, University of Granada, Andalusian Regional Government
- Evelyne Muggli
- Department of Paediatrics, University of Melbourne
- Jia Chen
- Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai
- Mariana F. Fernández
- CIBER Epidemiología y Salud Pública (CIBERESP)
- Jorg Tost
- Laboratory for Epigenetics and Environment, Centre National de Recherche en Génomique Humaine, CEA – Institut de Biologie François Jacob
- Antonio Gómez-Martín
- Genomics Unit, GENYO. Centre for Genomics and Oncological Research, Pfizer, University of Granada, Andalusian Regional Government
- Stephanie J. London
- Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services
- Jordi Sunyer
- Universitat Pompeu Fabra
- Carmen J. Marsit
- Gangarosa Department of Environmental Health, Rollins School of Public Health at Emory University
- Johanna Lepeule
- University Grenoble Alpes, Inserm, CNRS, IAB
- Marie-France Hivert
- Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute
- Mariona Bustamante
- Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-021-24558-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Maternal smoking during pregnancy contributes to poor birth outcomes. Here the authors perform a meta-analysis of the associations between maternal smoking during pregnancy and placental DNA methylation and identify links between these and poor birth outcomes, which may better inform the mechanisms through which smoking impacts placental function and fetal growth.
