Cancers (Nov 2022)
Simultaneous Onset of Haematological Malignancy and COVID: An Epicovideha Survey
- Chiara Cattaneo,
- Jon Salmanton-García,
- Francesco Marchesi,
- Shaimaa El-Ashwah,
- Federico Itri,
- Barbora Weinbergerová,
- Maria Gomes Da Silva,
- Michelina Dargenio,
- Julio Dávila-Valls,
- Sonia Martín-Pérez,
- Francesca Farina,
- Jaap Van Doesum,
- Toni Valković,
- Caroline Besson,
- Christian Bjørn Poulsen,
- Alberto López-García,
- Pavel Žák,
- Martin Schönlein,
- Klára Piukovics,
- Ozren Jaksic,
- Alba Cabirta,
- Natasha Ali,
- Uluhan Sili,
- Nicola Fracchiolla,
- Giulia Dragonetti,
- Tatjana Adžić-Vukičević,
- Monia Marchetti,
- Marina Machado,
- Andreas Glenthøj,
- Olimpia Finizio,
- Fatih Demirkan,
- Ola Blennow,
- Maria Chiara Tisi,
- Ali S. Omrani,
- Milan Navrátil,
- Zdeněk Ráčil,
- Jan Novák,
- Gabriele Magliano,
- Moraima Jiménez,
- Carolina Garcia-Vidal,
- Nurettin Erben,
- Maria Ilaria Del Principe,
- Caterina Buquicchio,
- Rui Bergantim,
- Josip Batinić,
- Murtadha Al-Khabori,
- Luisa Verga,
- Tomáš Szotkowski,
- Michail Samarkos,
- Irati Ormazabal-Vélez,
- Stef Meers,
- Johan Maertens,
- László Imre Pinczés,
- Martin Hoenigl,
- Ľuboš Drgoňa,
- Annarosa Cuccaro,
- Yavuz M. Bilgin,
- Avinash Aujayeb,
- Laman Rahimli,
- Stefanie Gräfe,
- Mariarita Sciumè,
- Miloš Mladenović,
- Gökçe Melis Çolak,
- Maria Vittoria Sacchi,
- Anna Nordlander,
- Caroline Berg Venemyr,
- Michaela Hanáková,
- Nicole García-Poutón,
- Ziad Emarah,
- Giovanni Paolo Maria Zambrotta,
- Raquel Nunes Rodrigues,
- Raul Cordoba,
- Gustavo-Adolfo Méndez,
- Monika M. Biernat,
- Oliver A. Cornely,
- Livio Pagano
Affiliations
- Chiara Cattaneo
- Hematology Unit, ASST-Spedali Civili, 25123 Brescia, Italy
- Jon Salmanton-García
- University of Cologne, Faculty of Medicine, University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50931 Cologne, Germany
- Francesco Marchesi
- Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy
- Shaimaa El-Ashwah
- Oncology Center, Mansoura University, Mansoura 35516, Egypt
- Federico Itri
- San Luigi Gonzaga Hospital, 10043 Orbassano, Italy
- Barbora Weinbergerová
- Masaryk University and University Hospital Brno—Department of Internal Medicine, Hematology and Oncology, 62500 Brno, Czech Republic
- Maria Gomes Da Silva
- Portuguese Institute of Oncology, 1099-023 Lisbon, Portugal
- Michelina Dargenio
- Hematology and Stem Cell Transplan Unit, Vito Fazzi, 73100 Lecce, Italy
- Julio Dávila-Valls
- Hospital Nuestra Señora de Sonsoles, 05004 Ávila, Spain
- Sonia Martín-Pérez
- Hospital Nuestra Señora de Sonsoles, 05004 Ávila, Spain
- Francesca Farina
- IRCCS Ospedale San Raffaele, 20132 Milan, Italy
- Jaap Van Doesum
- University Medical Center Groningen, 9713 GZ Groningen, The Netherlands
- Toni Valković
- University Hospital Centre Rijeka, 51000 Rijeka, Croatia
- Caroline Besson
- Centre Hospitalier de Versailles, Le Chesnay, Université Paris-Saclay, UVSQ, Inserm, Équipe “Exposome et Hérédité”, CESP, 94800 Villejuif, France
- Christian Bjørn Poulsen
- Zealand University Hospital, 4000 Roskilde, Denmark
- Alberto López-García
- Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, 28040 Madrid, Spain
- Pavel Žák
- University Hospital Hradec Králové, 50005 Hradec Králové, Czech Republic
- Martin Schönlein
- Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
- Klára Piukovics
- Department of Internal Medicine, South Division, Faculty of Medicine University of Szeged, 6720 Szeged, Hungary
- Ozren Jaksic
- University Hospital Dubrava, 10000 Zagreb, Croatia
- Alba Cabirta
- Department of Hematology, Vall d’Hebron Hospital Universitari, Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus, 08193 Barcelona, Spain
- Natasha Ali
- Aga Khan University, 74000 Karachi, Pakistan
- Uluhan Sili
- Department of Infectious Diseases and Clinical Microbiology, School of Medicine, Marmara University, 34854 Istanbul, Turkey
- Nicola Fracchiolla
- Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
- Giulia Dragonetti
- Hematology Unit, Fondazione Policlinico Universitario Agostino Gemelli—IRCCS, 00168 Rome, Italy
- Tatjana Adžić-Vukičević
- COVID Hospital “Batajnica”, 11000 Belgrade, Serbia
- Monia Marchetti
- Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy
- Marina Machado
- Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28009 Madrid, Spain
- Andreas Glenthøj
- Department of Hematology, Copenhagen University Hospital—Rigshospitalet, DK-2100 Copenhagen, Denmark
- Olimpia Finizio
- UOC Hematology, AORN Cardarelli, 80131 Naples, Italy
- Fatih Demirkan
- Dokuz Eylul University, Division of Hematology, 35340 Izmir, Turkey
- Ola Blennow
- Department of Infectious Diseases, Karolinska University Hospital, 17176 Stockholm, Sweden
- Maria Chiara Tisi
- Ospedale San Bortolo, 36100 Vicenza, Italy
- Ali S. Omrani
- Communicable Disease Center, Hamad Medical Corporation, Doha 3050, Qatar
- Milan Navrátil
- University Hospital Ostrava, 70852 Ostrava, Czech Republic
- Zdeněk Ráčil
- Institute of Hematology and Blood Transfusion, 12800 Prague, Czech Republic
- Jan Novák
- Department of Hematology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, 12808 Prague, Czech Republic
- Gabriele Magliano
- ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy
- Moraima Jiménez
- Department of Hematology, University Hospital Vall d’Hebron, Experimental Hematology, 08035 Barcelona, Spain
- Carolina Garcia-Vidal
- Department of Infectious Diseases, Hospital Clinic de Barcelona, University of Barcelona, IDIBAPS, 08035 Barcelona, Spain
- Nurettin Erben
- Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Eskisehir Osmangazi University, 26040 Eskisehir, Turkey
- Maria Ilaria Del Principe
- Hematology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy
- Caterina Buquicchio
- Ematologia Con Trapianto, Ospedale Dimiccoli Barletta, 70051 Barletta, Italy
- Rui Bergantim
- Centro Hospitalar e Universitário São João, 4200-319 Porto, Portugal
- Josip Batinić
- University Hospital Centre Zagreb, 10000 Zagreb, Croatia
- Murtadha Al-Khabori
- Sultan Qaboos University Hospital, Muscat 123, Oman
- Luisa Verga
- Azienda Ospedaliera San Gerardo—Monza, 20900 Monza, Italy
- Tomáš Szotkowski
- University Hospital Olomouc, 77900 Olomouc, Czech Republic
- Michail Samarkos
- Laikon Hospital, 11527 Athens, Greece
- Irati Ormazabal-Vélez
- Hospital Universitario de Navarra, 31008 Iruña-Pamplona, Spain
- Stef Meers
- AZ KLINA, 2930 Brasschaat, Belgium
- Johan Maertens
- KU Leuven, 3000 Leuven, Belgium
- László Imre Pinczés
- Division of Hematology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary
- Martin Hoenigl
- Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, San Diego, CA 92093, USA
- Ľuboš Drgoňa
- Department of Oncohematology, Comenius University and National Cancer Institute, 81499 Bratislava, Slovakia
- Annarosa Cuccaro
- Hematology Unit, Center for Translational Medicine, Azienda USL Toscana NordOvest, 55100 Livorno, Italy
- Yavuz M. Bilgin
- Department of Internal Medicine, ADRZ, 4462 RA Goes, The Netherlands
- Avinash Aujayeb
- Northumbria Healthcare, Newcastle NE29 8NH, UK
- Laman Rahimli
- University of Cologne, Faculty of Medicine, University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50931 Cologne, Germany
- Stefanie Gräfe
- University of Cologne, Faculty of Medicine, University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50931 Cologne, Germany
- Mariarita Sciumè
- Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
- Miloš Mladenović
- COVID Hospital “Batajnica”, 11000 Belgrade, Serbia
- Gökçe Melis Çolak
- Department of Infectious Diseases and Clinical Microbiology, School of Medicine, Marmara University, 34854 Istanbul, Turkey
- Maria Vittoria Sacchi
- Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy
- Anna Nordlander
- Department of Infectious Diseases, Karolinska University Hospital, 17176 Stockholm, Sweden
- Caroline Berg Venemyr
- Department of Hematology, Copenhagen University Hospital—Rigshospitalet, DK-2100 Copenhagen, Denmark
- Michaela Hanáková
- Institute of Hematology and Blood Transfusion, 12800 Prague, Czech Republic
- Nicole García-Poutón
- Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus, 08035 Barcelona, Spain
- Ziad Emarah
- Oncology Center, Mansoura University, Mansoura 35516, Egypt
- Giovanni Paolo Maria Zambrotta
- Sultan Qaboos University Hospital, Muscat 123, Oman
- Raquel Nunes Rodrigues
- Portuguese Institute of Oncology, 1099-023 Lisbon, Portugal
- Raul Cordoba
- Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, 28040 Madrid, Spain
- Gustavo-Adolfo Méndez
- Hospital Escuela de Agudos Dr. Ramón Madariaga, Posadas 3736, Argentina
- Monika M. Biernat
- Department of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, 50-425 Wroclaw, Poland
- Oliver A. Cornely
- University of Cologne, Faculty of Medicine, University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50931 Cologne, Germany
- Livio Pagano
- Hematology Unit, Fondazione Policlinico Universitario Agostino Gemelli—IRCCS, 00168 Rome, Italy
- DOI
- https://doi.org/10.3390/cancers14225530
- Journal volume & issue
-
Vol. 14,
no. 22
p. 5530
Abstract
Background: The outcome of patients with simultaneous diagnosis of haematological malignancies (HM) and COVID-19 is unknown and there are no specific treatment guidelines. Methods: We describe the clinical features and outcome of a cohort of 450 patients with simultaneous diagnosis of HM and COVID-19 registered in the EPICOVIDEHA registry between March 2020 to February 2022. Results: Acute leukaemia and lymphoma were the most frequent HM (35.8% and 35.1%, respectively). Overall, 343 (76.2%) patients received treatment for HM, which was delayed for longer than one month since diagnosis in 57 (16.6%). An overall response rate was observed in 140 (40.8%) patients after the first line of treatment. After a median follow-up of 35 days, overall mortality was 177/450 (39.3%); 30-day mortality was significantly higher in patients not receiving HM treatment (42.1%) than in those receiving treatment (27.4%, p = 0.004), either before and/or after COVID-19, or compared to patients receiving HM treatment at least after COVID-19 (15.2%, p 500/mcl at COVID-19 onset was protective. Conclusions: HM treatment should be delivered as soon as possible for patients with simultaneous diagnosis of COVID-19 and HM requiring immediate therapy.
Keywords