Communications Biology (Jul 2022)
Mitochondria dysfunction in Charcot Marie Tooth 2B Peripheral Sensory Neuropathy
- Yingli Gu,
- Flora Guerra,
- Mingzheng Hu,
- Alexander Pope,
- Kijung Sung,
- Wanlin Yang,
- Simone Jetha,
- Thomas A. Shoff,
- Tessanya Gunatilake,
- Owen Dahlkamp,
- Linda Zhixia Shi,
- Fiore Manganelli,
- Maria Nolano,
- Yue Zhou,
- Jianqing Ding,
- Cecilia Bucci,
- Chengbiao Wu
Affiliations
- Yingli Gu
- Department of Neurosciences, University of California San Diego
- Flora Guerra
- Department of Biological and Environmental Sciences and Technologies (DiSTeBA), Università del Salento
- Mingzheng Hu
- Department of Neurosciences, University of California San Diego
- Alexander Pope
- Department of Neurosciences, University of California San Diego
- Kijung Sung
- Department of Neurosciences, University of California San Diego
- Wanlin Yang
- Department of Neurosciences, University of California San Diego
- Simone Jetha
- Department of Neurosciences, University of California San Diego
- Thomas A. Shoff
- Department of Neurosciences, University of California San Diego
- Tessanya Gunatilake
- Department of Neurosciences, University of California San Diego
- Owen Dahlkamp
- Department of Neurosciences, University of California San Diego
- Linda Zhixia Shi
- Department of Bioengineering, University of California San Diego
- Fiore Manganelli
- Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”
- Maria Nolano
- Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”
- Yue Zhou
- School of Biomedical Engineering, Shanghai Jiao Tong University
- Jianqing Ding
- Institute of Neurology, Ruijin Hospital, Shanghai JiaoTong University School of Medicine
- Cecilia Bucci
- Department of Biological and Environmental Sciences and Technologies (DiSTeBA), Università del Salento
- Chengbiao Wu
- Department of Neurosciences, University of California San Diego
- DOI
- https://doi.org/10.1038/s42003-022-03632-1
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 17
Abstract
The Rab7V162M mutation associated with Charcot Marie Tooth 2B peripheral neuropathy causes mitochondrial fragmentation in patient-derived fibroblasts and primary cultured dorsal root ganglion sensory neurons from E18 mouse embryos.
