Protection of calves by a prefusion-stabilized bovine RSV F vaccine
Baoshan Zhang,
Lei Chen,
Chiara Silacci,
Michelle Thom,
Jeffrey C. Boyington,
Aliaksandr Druz,
M. Gordon Joyce,
Efrain Guzman,
Wing- Pui Kong,
Yen-Ting Lai,
Guillaume B. E. Stewart-Jones,
Yaroslav Tsybovsky,
Yongping Yang,
Tongqing Zhou,
Ulrich Baxa,
John R. Mascola,
Davide Corti,
Antonio Lanzavecchia,
Geraldine Taylor,
Peter D. Kwong
Affiliations
Baoshan Zhang
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Lei Chen
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Chiara Silacci
Institute for Research in Biomedicine, Università della Svizzera italiana
Michelle Thom
The Pirbright Institute
Jeffrey C. Boyington
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Aliaksandr Druz
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
M. Gordon Joyce
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Efrain Guzman
The Pirbright Institute
Wing- Pui Kong
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Yen-Ting Lai
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Guillaume B. E. Stewart-Jones
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Yaroslav Tsybovsky
Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
Yongping Yang
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Tongqing Zhou
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Ulrich Baxa
Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
John R. Mascola
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Davide Corti
Institute for Research in Biomedicine, Università della Svizzera italiana
Antonio Lanzavecchia
Institute for Research in Biomedicine, Università della Svizzera italiana
Geraldine Taylor
The Pirbright Institute
Peter D. Kwong
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Respiratory disease: A bovine model for respiratory syncytial virus vaccines Researchers have produced a vaccine that protects against bovine respiratory syncytial virus (bRSV) in calves, with implications for humans. An international team comprising Geraldine Taylor, The Pirbright Institute, UK, Davide Corti and Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland, and Peter Kwong, Vaccine Research Center, NIAID, NIH, United States, and their teams constructed the subunit vaccine from an engineered bRSVfusion (F) glycoprotein that protected challenged calves by generating a highly protective immune response. This approach allays some of the dangers of whole-virus vaccines. The results warrant further investigation, as current bRSV vaccines have significant downsides.Moreover, as the engineered bRSV F glycoprotein is structurally and reactively similar to the prefusion-stabilized human RSV (hRSV) F glycoprotein, the findings highlight potential benefits of similar vaccines in humans, as no licensed hRSV vaccine is currently available.
