Sorghum polyphenol suppresses the growth as well as metastasis of colon cancer xenografts through co-targeting jak2/STAT3 and PI3K/Akt/mTOR pathways

Pramod Darvin; Youn Hee Joung; Nipin S P; Dong Young Kang; Hyo Joo Byun; Dae Yong Hwang; Kwang Hyun Cho; Kyung Do Park; Hak Kyo Lee; Young Mok Yang

Journal of Functional Foods (May 2015)

Sorghum polyphenol suppresses the growth as well as metastasis of colon cancer xenografts through co-targeting jak2/STAT3 and PI3K/Akt/mTOR pathways

Pramod Darvin,
Youn Hee Joung,
Nipin S P,
Dong Young Kang,
Hyo Joo Byun,
Dae Yong Hwang,
Kwang Hyun Cho,
Kyung Do Park,
Hak Kyo Lee,
Young Mok Yang

Affiliations

Pramod Darvin: Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University Glocal Campus, Seoul 143-701, Republic of Korea
Youn Hee Joung: Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University Glocal Campus, Seoul 143-701, Republic of Korea
Nipin S P: Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University Glocal Campus, Seoul 143-701, Republic of Korea
Dong Young Kang: Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University Glocal Campus, Seoul 143-701, Republic of Korea
Hyo Joo Byun: Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University Glocal Campus, Seoul 143-701, Republic of Korea
Dae Yong Hwang: Department of Surgery, School of Medicine, Konkuk University, Seoul 143-701, Republic of Korea
Kwang Hyun Cho: National Institute of Animal Science, RDA, Cheonan 330-800, Republic of Korea
Kyung Do Park: Genomics Informatics Center, Hankyong National University, Anseong 456-749, Republic of Korea
Hak Kyo Lee: Genomics Informatics Center, Hankyong National University, Anseong 456-749, Republic of Korea; Corresponding author. Genomics Informatics Center, Hankyong National University, Anseong 456-749, Republic of Korea. Tel.: +82316705332; fax: +82316705339.
Young Mok Yang: Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University Glocal Campus, Seoul 143-701, Republic of Korea; Corresponding author. Department of Pathology, School of Medicine, and Institute of Biomedical Science and Technology, Konkuk University, Seoul 143-701, Republic of Korea. Tel.: +82220307812; fax: +82220307845.

Journal volume & issue: Vol. 15
pp. 193 – 206

Abstract

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Sorghum contains phytochemicals that can protect against multiple forms of cancers. However, the underlying molecular targets and cellular mechanisms remain unknown. We investigated the role of Hwanggeumchal sorghum extracts (HSE) on colon cancer cells. We found HSE inhibited the proliferation of human colon cancer cells in a dose-dependent manner by inducing G1 phase arrest and apoptosis. Likewise, it suppressed the Jak2/STAT3 and PI3K/AKT/mTOR pathways. Studies on STAT3 transcription regulatory functions showed HSE inhibited the STAT3/DNA binding and transcription promoter activity. Thereby the expression of STAT3 downstream targets VEGF and VEGF-R2 were dropped. Furthermore, HSE treatment suppressed tumor growth and pulmonary metastasis in animal models. Together, these findings suggested that the targeted inhibition of Jak2/STAT3 and PI3K/Akt/mTOR contribute to cancer therapy potential of H. sorghum (HS). Thus, use of sorghum as a dietary supplement has the potential as a nutraceutical to prevent the onset of colon cancer, without any side effects.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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