Taurine reduces hyperactive behavior in SHR rats through upregulating the proportion of CD4+CD25+Foxp3+ regulatory T cells

Vincent Chin-Hung Chen; Chun-Ching Chiu; Jun-Cheng Weng; Li-Jeng Chen; Jing Yi Siow; Tsai-Ching Hsu; Bor-Show Tzang

Journal of Functional Foods (May 2019)

Taurine reduces hyperactive behavior in SHR rats through upregulating the proportion of CD4+CD25+Foxp3+ regulatory T cells

Vincent Chin-Hung Chen,
Chun-Ching Chiu,
Jun-Cheng Weng,
Li-Jeng Chen,
Jing Yi Siow,
Tsai-Ching Hsu,
Bor-Show Tzang

Affiliations

Vincent Chin-Hung Chen: Department of Psychiatry, Chang Gung Medical Foundation, Chiayi Chang Gung Memorial Hospital, 613 Chiayi, Taiwan; Department of Psychiatry, Chang Gung University, 333 Taoyuan, Taiwan
Chun-Ching Chiu: Department of Neurology and Department of Medical Intensive Care Unit, Changhua Christian Hospital, 500 Changhua, Taiwan
Jun-Cheng Weng: Department of Psychiatry, Chang Gung Medical Foundation, Chiayi Chang Gung Memorial Hospital, 613 Chiayi, Taiwan; Department of Medical Imaging and Radiological Sciences, Chang Gung University, 333 Taoyuan, Taiwan
Li-Jeng Chen: Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, 402 Taichung, Taiwan
Jing Yi Siow: Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, 402 Taichung, Taiwan
Tsai-Ching Hsu: Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, 402 Taichung, Taiwan; Clinical Laboratory, Chung Shan Medical University Hospital, 402 Taichung, Taiwan; Corresponding authors at: Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, 402 Taichung, Taiwan.
Bor-Show Tzang: Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, 402 Taichung, Taiwan; Clinical Laboratory, Chung Shan Medical University Hospital, 402 Taichung, Taiwan; Department of Biochemistry, School of Medicine, Chung Shan Medical University, 402 Taichung, Taiwan; Corresponding authors at: Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, 402 Taichung, Taiwan.

Journal volume & issue: Vol. 56
pp. 312 – 320

Abstract

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Attention deficit hyperactivity disorder (ADHD) is a most common mental illness in both children and adults. Our recent studies revealed that high-dose taurine improves hyperactivity in SHR rats by reducing mALFF signal and striatal dopamine uptake. This study further revealed the association between immune factors and hyperactivity in SHR rats fed with high-dose taurine. A positive correlation was detected between systolic blood pressure (SBP) and horizontal locomotion in SHR rats fed with high-dose taurine. Significantly higher striatal Hsp27 and galectin-3 were detected in SHR rats fed with high-dose taurine. Significantly lower IL-2 and IL-6 were detected in SHR rats fed with high-dose taurine, whereas significantly higher IL-10 was detected. Significantly increased splenic CD4+CD25+Foxp3+ regulatory T cells was detected in SHR rats fed with high-dose taurine with a negative correlation. These findings suggest that high-dose taurine reduce hyperactive behavior in SHR rats probably via multifactorial modulation on immune system.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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