Romanian Journal of Laboratory Medicine (2015-12-01)

Pulmonary heart valve replacement using stabilized acellular xenogeneic scaffolds; effects of seeding with autologous stem cells

  • Harpa Marius Mihai,
  • Movileanu Ionela,
  • Sierad Leslie Neil,
  • Cotoi Ovidiu Simion,
  • Suciu Horatiu,
  • Sircuta Carmen,
  • Preda Terezia,
  • Nistor Dan,
  • Branzaniuc Klara,
  • Deac Radu,
  • Dandel Michael,
  • Gurzu Simona,
  • Harceaga Lucian,
  • Olah Peter,
  • Simionescu Agneta,
  • Simionescu Dan

DOI
https://doi.org/10.1515/rrlm-2015-0046
Journal volume & issue
Vol. 23, no. 4
pp. 415 – 430

Abstract

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Background: We hypothesized that an ideal heart valve replacement would be acellular valve root scaffolds seeded with autologous stem cells. To test this hypothesis, we prepared porcine acellular pulmonary valves, seeded them with autologous adipose derived stem cells (ADSCs) and implanted them in sheep and compared them to acellular valves.

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