Halofuginone for cancer treatment: A systematic review of efficacy and molecular mechanisms

Li Mi; Yujie Zhang; Anping Su; Minghai Tang; Zhichao Xing; Ting He; Wenshuang Wu; Zhihui Li

Journal of Functional Foods (Nov 2022)

Halofuginone for cancer treatment: A systematic review of efficacy and molecular mechanisms

Li Mi,
Yujie Zhang,
Anping Su,
Minghai Tang,
Zhichao Xing,
Ting He,
Wenshuang Wu,
Zhihui Li

Affiliations

Li Mi: Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China
Yujie Zhang: Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China
Anping Su: Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China
Minghai Tang: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China
Zhichao Xing: Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China
Ting He: Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China
Wenshuang Wu: Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China; Corresponding authors at: Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, China.
Zhihui Li: Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China; Corresponding authors at: Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, China.

Journal volume & issue: Vol. 98
p. 105237

Abstract

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Cancer is still considered a “hopeless case”, which seriously endangers human health. Therefore, it is of great significance to research and develop novel anticancer drugs. Active natural products play an important role in anticancer drug discovery by providing lead compounds. Halofuginone (HF), as a derivative of febrifugine, an alkaloid originally isolated from the plant Dichroa febrifuga, is used for the prevention and treatment of coccidiosis and malaria in poultry. In recent years, HF has shown excellent anticancer activity and great clinical potential for treating various cancers. Despite enormous progress, a thorough elaboration of the proposed mechanism and mode of action is absent. Herein, we provide a comprehensive review of the most recent anticancer studies reported for HF and a rationale for further exploring the potential application of HF in overcoming cancer in the future.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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