Antioxidative mechanisms and anticolitic potential of Desmodium styracifolium (Osb.) Merr. in DSS-induced colitic mice

Xia Li; Chengxin Liu; Jun Liang; Li Zhou; Jing Li; Huiying Chen; Tiemin Jiang; Yuan Guan; Hock Eng Khoo

Journal of Functional Foods (Jun 2022)

Antioxidative mechanisms and anticolitic potential of Desmodium styracifolium (Osb.) Merr. in DSS-induced colitic mice

Xia Li,
Chengxin Liu,
Jun Liang,
Li Zhou,
Jing Li,
Huiying Chen,
Tiemin Jiang,
Yuan Guan,
Hock Eng Khoo

Affiliations

Xia Li: Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, 541006 Guilin, China
Chengxin Liu: Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, 541006 Guilin, China
Jun Liang: College of Materials Science and Engineering, Guilin University of Technology, 541004 Guilin, China
Li Zhou: College of Materials Science and Engineering, Guilin University of Technology, 541004 Guilin, China
Jing Li: Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, 541006 Guilin, China
Huiying Chen: Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, 541006 Guilin, China
Tiemin Jiang: Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, 541006 Guilin, China
Yuan Guan: Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, 541006 Guilin, China; Corresponding authors at Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, 541006 Guilin, China.
Hock Eng Khoo: Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, 541006 Guilin, China; Corresponding authors at Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, 541006 Guilin, China.

Journal volume & issue: Vol. 93
p. 105077

Abstract

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This study aimed to determine the anticolitic effect of Desmodium styracifolium (DS) extract in ulcerative colitis (UC) mice and its possible antioxidative mechanisms. Phenolic antioxidants and free radical scavenging activities of the herb extract were determined. LCMS was used to identify phenolic compounds in the herbal extract. Ulcerative colitis in C57BL/6 SPF mice was induced with dextran sodium sulfate (DSS). The mice were treated with two doses of the DS extract during the 7-day experiment. Colon length, spleen weight, histopathological changes in colonic tissues, and disease activity index (DAI) of the mice were measured. The bioactive antioxidants in DS extract were flavonoids. The DS extract-treated UC mice had a lower DAI than the untreated UC mice. Also, the herbal treatment had downregulated expressions of proinflammatory cytokine genes in the colonic tissues of the mice compared to the control. Therefore, it is a potent anti-inflammatory agent for reducing UC symptoms.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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