DESIGN OF RHAMNOLIPID-ETHYL THIOSULFANILATE NANOPARTICLES, PHYSICOCHEMICAL CHARACTERISTICS, BIOLOGICAL ACTIVITY
NATALYA SHCHEGLOVA ,
ALLA PROKOPALO ,
VIRA LUBENETS ,
OLEKSANDR RESHETNYAK,
OLENA KARPENKO
Affiliations
NATALYA SHCHEGLOVA
Department of Physical Chemistry of Fossil Fuels Institute of Physical-Organic Chemistry and Coal Chemistry named after L. M. Lytvynenko National Academy of Sciences of Ukraine, 3a Naukova Str., 79060, Lviv, Ukraine
ALLA PROKOPALO
Department of Physical Chemistry of Fossil Fuels Institute of Physical-Organic Chemistry and Coal Chemistry named after L. M. Lytvynenko National Academy of Sciences of Ukraine, 3a Naukova Str., 79060, Lviv, Ukraine & Ivan Franko National University of Lviv, Faculty of Chemistry, Department of Physical and Colloid Chemistry, 6 Kyryla i Mefodiya Str., 79005, Lviv, Ukraine
VIRA LUBENETS
National University “Lviv Polytechnic”, Institute of Chemistry and Chemical Technology, Department of Technology of Biologically Active Substances, Pharmacy, and Biotechnology, 12 S. Bandery Str., 79013, Lviv, Ukraine
OLEKSANDR RESHETNYAK
Ivan Franko National University of Lviv, Faculty of Chemistry, Department of Physical and Colloid Chemistry, 6 Kyryla i Mefodiya Str., 79005, Lviv, Ukraine
OLENA KARPENKO
Department of Physical Chemistry of Fossil Fuels Institute of Physical-Organic Chemistry and Coal Chemistry named after L. M. Lytvynenko National Academy of Sciences of Ukraine, 3a Naukova Str., 79060, Lviv, Ukraine
Nowadays, the urgent task of pharmacy and chemistry is to increase the bioavailability and effectiveness of medicines to overcome the resistance of pathogens. Nanoparticles based on biologically active substances have a special potential for solving this problem. The purpose of this work was the synthesis of nanoparticles of ethyl thiosulfanilate (ETS) with rhamnolipids (RL), establishment of physicochemical properties and antimicrobial action, comparison of the activity of nanoparticles and ETS-RL compositions. Using the methods of dynamic light scattering and scanning electron microscopy, it was established that aqueous solutions of the obtained ETS-RL compositions and nanoparticles formed spherical micelles, with hydrodynamic radii of 138 nm and 109 nm, respectively. The influence of the size of nanoparticles on their properties is shown, in particular, solutions of nanoparticles have a higher emulsifying and wetting ability compared to compositions. Solutions of ETS-RL compositions and nanoparticles show antimicrobial activity against Staphylococcus aureus, Micrococcus luteus, Escherichia coli, Alternaria alternata, Fusarium oxysporum, Candida tenuis. The obtained results testify to the effectiveness of the developed compositions and nanoparticles of ETS-RL and confirm the perspective of their use in pharmacy.
