npj Vaccines (Mar 2024)

Immune response induced by standard and fractional doses of 17DD yellow fever vaccine

  • Thais Abdala-Torres,
  • Ana Carolina Campi-Azevedo,
  • Rosiane Aparecida da Silva-Pereira,
  • Luara Isabela dos Santos,
  • Priscilla Miranda Henriques,
  • Ismael Artur Costa-Rocha,
  • Dayane Andriotti Otta,
  • Vanessa Peruhype-Magalhães,
  • Andréa Teixeira-Carvalho,
  • Márcio Sobreira Silva Araújo,
  • Eder Gatti Fernandes,
  • Helena Keico Sato,
  • Francieli Fontana Sutile Tardetti Fantinato,
  • Carla Magda Allan Santos Domingues,
  • Esper Georges Kallás,
  • Helena Tomoko Iwashita Tomiyama,
  • Jandira Aparecida Campos Lemos,
  • Jordana Grazziela Coelho-dos-Reis,
  • Sheila Maria Barbosa de Lima,
  • Waleska Dias Schwarcz,
  • Adriana de Souza Azevedo,
  • Gisela Freitas Trindade,
  • Ana Paula Dinis Ano Bom,
  • Andrea Marques Vieira da Silva,
  • Camilla Bayma Fernandes,
  • Luiz Antônio Bastos Camacho,
  • Maria de Lourdes de Sousa Maia,
  • Collaborative Group for Studies of Yellow Fever Vaccine,
  • Olindo Assis Martins-Filho,
  • Lis Ribeiro do Valle do Antonelli

DOI
https://doi.org/10.1038/s41541-024-00836-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 16

Abstract

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Abstract The re-emergence of yellow fever (YF) urged new mass vaccination campaigns and, in 2017, the World Health Organization approved the use of the fractional dose (FD) of the YF vaccine due to stock shortage. In an observational cross-sectional investigation, we have assessed viremia, antibodies, soluble mediators and effector and memory T and B-cells induced by primary vaccination of volunteers with FD and standard dose (SD). Similar viremia and levels of antibodies and soluble markers were induced early after immunization. However, a faster decrease in the latter was observed after SD. The FD led to a sustained expansion of helper T-cells and an increased expression of activation markers on T-cells early after vaccination. Although with different kinetics, expansion of plasma cells was induced upon SD and FD immunization. Integrative analysis reveals that FD induces a more complex network involving follicular helper T cells and B-cells than SD. Our findings substantiate that FD can replace SD inducing robust correlates of protective immune response against YF.