Hepatoprotective effect of polysaccharide isolated from Sonneratia apetala fruits on acetaminophen-induced liver injury mice

Jingjing Liu; Yulin Wu; Yongfu Wang; Xiaoli Wu; Yucui Li; Changjun Gao; Yuhong Liu; Qian Zhang; Jian Cai; Ziren Su

Journal of Functional Foods (Nov 2021)

Hepatoprotective effect of polysaccharide isolated from Sonneratia apetala fruits on acetaminophen-induced liver injury mice

Jingjing Liu,
Yulin Wu,
Yongfu Wang,
Xiaoli Wu,
Yucui Li,
Changjun Gao,
Yuhong Liu,
Qian Zhang,
Jian Cai,
Ziren Su

Affiliations

Jingjing Liu: School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China; Fuyang Institute of Technology, Fuyang 236031, PR China
Yulin Wu: School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China
Yongfu Wang: School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China
Xiaoli Wu: Postdoctoral Programme, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, PR China
Yucui Li: School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China
Changjun Gao: Guangdong Provincial Key Laboratory of Silviculture, Protection and Utilization, Guangzhou 510520, PR China; Guangdong Academy of Forestry, Guangzhou 510520, PR China
Yuhong Liu: School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China
Qian Zhang: Guangdong Provincial Key Laboratory of Silviculture, Protection and Utilization, Guangzhou 510520, PR China; Guangdong Academy of Forestry, Guangzhou 510520, PR China
Jian Cai: Guangdong Provincial Key Laboratory of Silviculture, Protection and Utilization, Guangzhou 510520, PR China; Guangdong Academy of Forestry, Guangzhou 510520, PR China; Corresponding authors at: Guangdong Provincial Key Laboratory of Silviculture, Protection and Utilization, Guangzhou 510520, PR China (J. Cai). School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China (Z. Su).
Ziren Su: School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China; Corresponding authors at: Guangdong Provincial Key Laboratory of Silviculture, Protection and Utilization, Guangzhou 510520, PR China (J. Cai). School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China (Z. Su).

Journal volume & issue: Vol. 86
p. 104685

Abstract

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Sonneratia apetala fruits are edible and medicinal. Our previous report demonstrated that the S. apetala fruits extract had the hepatoprotective activity. In the study, an acidic polysaccharide named SAP-2 was isolated and purified from S. apetala fruits. The preliminary structure of SAP-2 was characterized, and its hepatoprotective effect and the mechanism of action in Nrf2 signaling pathway were also evaluated in acetaminophen (acetyl-para-aminophenol, APAP)-induced liver damaged mice. Results manifested that SAP-2 could alleviate histological changes, inhibit oxidative stress and enhance antioxidant system via activating of Nrf2 signaling pathway on APAP-induced hepatic injury. These results indicated that S. apetala fruits could be developed into a new source of potential natural antioxidant and functional food for hepatoprotection.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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