Nature Communications (Dec 2021)
Meta-analyses identify DNA methylation associated with kidney function and damage
- Pascal Schlosser,
- Adrienne Tin,
- Pamela R. Matias-Garcia,
- Chris H. L. Thio,
- Roby Joehanes,
- Hongbo Liu,
- Antoine Weihs,
- Zhi Yu,
- Anselm Hoppmann,
- Franziska Grundner-Culemann,
- Josine L. Min,
- Adebowale A. Adeyemo,
- Charles Agyemang,
- Johan Ärnlöv,
- Nasir A. Aziz,
- Andrea Baccarelli,
- Murielle Bochud,
- Hermann Brenner,
- Monique M. B. Breteler,
- Cristian Carmeli,
- Layal Chaker,
- John C. Chambers,
- Shelley A. Cole,
- Josef Coresh,
- Tanguy Corre,
- Adolfo Correa,
- Simon R. Cox,
- Niek de Klein,
- Graciela E. Delgado,
- Arce Domingo-Relloso,
- Kai-Uwe Eckardt,
- Arif B. Ekici,
- Karlhans Endlich,
- Kathryn L. Evans,
- James S. Floyd,
- Myriam Fornage,
- Lude Franke,
- Eliza Fraszczyk,
- Xu Gao,
- Xīn Gào,
- Mohsen Ghanbari,
- Sahar Ghasemi,
- Christian Gieger,
- Philip Greenland,
- Megan L. Grove,
- Sarah E. Harris,
- Gibran Hemani,
- Peter Henneman,
- Christian Herder,
- Steve Horvath,
- Lifang Hou,
- Mikko A. Hurme,
- Shih-Jen Hwang,
- Marjo-Riitta Jarvelin,
- Sharon L. R. Kardia,
- Silva Kasela,
- Marcus E. Kleber,
- Wolfgang Koenig,
- Jaspal S. Kooner,
- Holly Kramer,
- Florian Kronenberg,
- Brigitte Kühnel,
- Terho Lehtimäki,
- Lars Lind,
- Dan Liu,
- Yongmei Liu,
- Donald M. Lloyd-Jones,
- Kurt Lohman,
- Stefan Lorkowski,
- Ake T. Lu,
- Riccardo E. Marioni,
- Winfried März,
- Daniel L. McCartney,
- Karlijn A. C. Meeks,
- Lili Milani,
- Pashupati P. Mishra,
- Matthias Nauck,
- Ana Navas-Acien,
- Christoph Nowak,
- Annette Peters,
- Holger Prokisch,
- Bruce M. Psaty,
- Olli T. Raitakari,
- Scott M. Ratliff,
- Alex P. Reiner,
- Sylvia E. Rosas,
- Ben Schöttker,
- Joel Schwartz,
- Sanaz Sedaghat,
- Jennifer A. Smith,
- Nona Sotoodehnia,
- Hannah R. Stocker,
- Silvia Stringhini,
- Johan Sundström,
- Brenton R. Swenson,
- Maria Tellez-Plaza,
- Joyce B. J. van Meurs,
- Jana V. van Vliet-Ostaptchouk,
- Andrea Venema,
- Niek Verweij,
- Rosie M. Walker,
- Matthias Wielscher,
- Juliane Winkelmann,
- Bruce H. R. Wolffenbuttel,
- Wei Zhao,
- Yinan Zheng,
- Estonian Biobank Research Team,
- Genetics of DNA Methylation Consortium,
- Marie Loh,
- Harold Snieder,
- Daniel Levy,
- Melanie Waldenberger,
- Katalin Susztak,
- Anna Köttgen,
- Alexander Teumer
Affiliations
- Pascal Schlosser
- Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg
- Adrienne Tin
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Pamela R. Matias-Garcia
- Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Chris H. L. Thio
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Roby Joehanes
- Framingham Heart Study
- Hongbo Liu
- Department of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine
- Antoine Weihs
- Department of Psychiatry and Psychotherapy, University Medicine Greifswald
- Zhi Yu
- Program in Medical and Population Genetics, Broad Institute
- Anselm Hoppmann
- Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg
- Franziska Grundner-Culemann
- Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg
- Josine L. Min
- MRC Integrative Epidemiology Unit, University of Bristol
- Adebowale A. Adeyemo
- Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- Charles Agyemang
- Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, University of Amsterdam
- Johan Ärnlöv
- Department of Neurobiology, Care Sciences and Society (NVS), Family Medicine and Primary Care Unit, Karolinska Institutet
- Nasir A. Aziz
- Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE)
- Andrea Baccarelli
- Laboratory of Environmental Precision Health, Mailman School of Public Health, Columbia University
- Murielle Bochud
- Center for Primary Care and Public Health (Unisanté), University of Lausanne
- Hermann Brenner
- German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research
- Monique M. B. Breteler
- Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE)
- Cristian Carmeli
- Center for Primary Care and Public Health (Unisanté), University of Lausanne
- Layal Chaker
- Department of Epidemiology, Erasmus University Medical Center
- John C. Chambers
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Shelley A. Cole
- Texas Biomedical Research Institute
- Josef Coresh
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Tanguy Corre
- Center for Primary Care and Public Health (Unisanté), University of Lausanne
- Adolfo Correa
- Department of Medicine, University of Mississippi Medical Center
- Simon R. Cox
- Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh
- Niek de Klein
- Department of Genetics, University Medical Center Groningen, University of Groningen
- Graciela E. Delgado
- Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University
- Arce Domingo-Relloso
- Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institute
- Kai-Uwe Eckardt
- Department of Nephrology and Hypertension, University of Erlangen-Nürnberg
- Arif B. Ekici
- Institute of Human Genetics, Friedrich-Alexander-UniversitätErlangen-Nürnberg
- Karlhans Endlich
- Department of Anatomy and Cell Biology, University Medicine Greifswald
- Kathryn L. Evans
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh
- James S. Floyd
- Department of Medicine, University of Washington
- Myriam Fornage
- Brown Foundation Institute of Molecular Medicine, McGovern Medical School
- Lude Franke
- Department of Genetics, University Medical Center Groningen, University of Groningen
- Eliza Fraszczyk
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Xu Gao
- Laboratory of Environmental Precision Health, Mailman School of Public Health, Columbia University
- Xīn Gào
- German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research
- Mohsen Ghanbari
- Department of Epidemiology, Erasmus University Medical Center
- Sahar Ghasemi
- Department of Psychiatry and Psychotherapy, University Medicine Greifswald
- Christian Gieger
- Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Philip Greenland
- Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Megan L. Grove
- Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Sarah E. Harris
- Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh
- Gibran Hemani
- MRC Integrative Epidemiology Unit, University of Bristol
- Peter Henneman
- Department of Clinical Genetics, Amsterdam Reproduction & Development Research Institute, Amsterdam University Medical Centres, University of Amsterdam
- Christian Herder
- Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf
- Steve Horvath
- Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles
- Lifang Hou
- Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Mikko A. Hurme
- Department of Microbiology and Immunology, Faculty of Medicine and Health Technology, Tampere University
- Shih-Jen Hwang
- Framingham Heart Study
- Marjo-Riitta Jarvelin
- Department of Epidemiology and Biostatistics, MRC–PHE Centre for Environment & Health, School of Public Health, Imperial College London
- Sharon L. R. Kardia
- Department of Epidemiology, School of Public Health, University of Michigan
- Silva Kasela
- Estonian Genome Centre, Institute of Genomics, University of Tartu
- Marcus E. Kleber
- Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University
- Wolfgang Koenig
- Deutsches Herzzentrum München, Technische Universität München
- Jaspal S. Kooner
- Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust
- Holly Kramer
- Departments of Public Health Science and Medicine, Loyola University Chicago
- Florian Kronenberg
- Institute of Genetic Epidemiology, Medical University of Innsbruck
- Brigitte Kühnel
- Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Terho Lehtimäki
- Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University
- Lars Lind
- Department of Medical Sciences, Uppsala University
- Dan Liu
- Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE)
- Yongmei Liu
- Department of Medicine, Division of Cardiology, Duke Molecular Physiology Institute, Duke University School of Medicine
- Donald M. Lloyd-Jones
- Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Kurt Lohman
- Department of Medicine, Division of Cardiology, Duke Molecular Physiology Institute, Duke University School of Medicine
- Stefan Lorkowski
- Institute of Nutritional Sciences, Friedrich Schiller University Jena
- Ake T. Lu
- Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles
- Riccardo E. Marioni
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh
- Winfried März
- Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University
- Daniel L. McCartney
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh
- Karlijn A. C. Meeks
- Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- Lili Milani
- Estonian Genome Centre, Institute of Genomics, University of Tartu
- Pashupati P. Mishra
- Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University
- Matthias Nauck
- DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald
- Ana Navas-Acien
- Department of Environmental Health Sciences, Columbia University Mailman School of Public Health
- Christoph Nowak
- Department of Neurobiology, Care Sciences and Society (NVS), Family Medicine and Primary Care Unit, Karolinska Institutet
- Annette Peters
- Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Holger Prokisch
- Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München
- Bruce M. Psaty
- Department of Medicine, University of Washington
- Olli T. Raitakari
- Research centre of Applied and Preventive Cardiovascular Medicine, University of Turku
- Scott M. Ratliff
- Department of Epidemiology, School of Public Health, University of Michigan
- Alex P. Reiner
- Department of Epidemiology, University of Washington
- Sylvia E. Rosas
- Joslin Diabetes Center
- Ben Schöttker
- German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research
- Joel Schwartz
- Department of Environmental Health, Harvard T.H. Chan School of Public Health
- Sanaz Sedaghat
- Division of Epidemiology and Community Health, School of Public Health, University of Minnesota
- Jennifer A. Smith
- Department of Epidemiology, School of Public Health, University of Michigan
- Nona Sotoodehnia
- Cardiovascular Health Research Unit, University of Washington
- Hannah R. Stocker
- German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research
- Silvia Stringhini
- Center for Primary Care and Public Health (Unisanté), University of Lausanne
- Johan Sundström
- Department of Medical Sciences, Uppsala University
- Brenton R. Swenson
- Cardiovascular Health Research Unit, University of Washington
- Maria Tellez-Plaza
- Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institute
- Joyce B. J. van Meurs
- Department of Internal Medicine, Erasmus Medical Center
- Jana V. van Vliet-Ostaptchouk
- Department of Endocrinology, University of Groningen, University Medical Center Groningen
- Andrea Venema
- Department of Clinical Genetics, Amsterdam Reproduction & Development Research Institute, Amsterdam University Medical Centres, University of Amsterdam
- Niek Verweij
- Department of Cardiology, University Medical Center Groningen, University of Groningen
- Rosie M. Walker
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh
- Matthias Wielscher
- Department of Epidemiology and Biostatistics, MRC–PHE Centre for Environment & Health, School of Public Health, Imperial College London
- Juliane Winkelmann
- Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München
- Bruce H. R. Wolffenbuttel
- Department of Endocrinology, University of Groningen, University Medical Center Groningen
- Wei Zhao
- Department of Epidemiology, School of Public Health, University of Michigan
- Yinan Zheng
- Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Estonian Biobank Research Team
- Genetics of DNA Methylation Consortium
- Marie Loh
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Harold Snieder
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Daniel Levy
- Framingham Heart Study
- Melanie Waldenberger
- Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Katalin Susztak
- Department of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine
- Anna Köttgen
- Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg
- Alexander Teumer
- DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald
- DOI
- https://doi.org/10.1038/s41467-021-27234-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Many genetic loci have been identified to be associated with kidney disease, but the molecular mechanisms are not well understood. Here, the authors perform epigenome-wide association studies on kidney function measures to identify epigenetic marks and pathways involved in kidney function.
