Nature Communications (Jun 2018)
Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment
- Diego Scheggia,
- Rosa Mastrogiacomo,
- Maddalena Mereu,
- Sara Sannino,
- Richard E. Straub,
- Marco Armando,
- Francesca Managò,
- Simone Guadagna,
- Fabrizio Piras,
- Fengyu Zhang,
- Joel E. Kleinman,
- Thomas M. Hyde,
- Sanne S. Kaalund,
- Maria Pontillo,
- Genny Orso,
- Carlo Caltagirone,
- Emiliana Borrelli,
- Maria A. De Luca,
- Stefano Vicari,
- Daniel R. Weinberger,
- Gianfranco Spalletta,
- Francesco Papaleo
Affiliations
- Diego Scheggia
- Department of Neuroscience and Brain Technologies, Genetics of Cognition laboratory, Istituto Italiano di Tecnologia
- Rosa Mastrogiacomo
- Department of Neuroscience and Brain Technologies, Genetics of Cognition laboratory, Istituto Italiano di Tecnologia
- Maddalena Mereu
- Department of Neuroscience and Brain Technologies, Genetics of Cognition laboratory, Istituto Italiano di Tecnologia
- Sara Sannino
- Department of Neuroscience and Brain Technologies, Genetics of Cognition laboratory, Istituto Italiano di Tecnologia
- Richard E. Straub
- Lieber Institute for Brain Development, Johns Hopkins University Medical Campus
- Marco Armando
- Department of Neuroscience, Bambino Gesù Children’s Hospital
- Francesca Managò
- Department of Neuroscience and Brain Technologies, Genetics of Cognition laboratory, Istituto Italiano di Tecnologia
- Simone Guadagna
- Department of Neuroscience and Brain Technologies, Genetics of Cognition laboratory, Istituto Italiano di Tecnologia
- Fabrizio Piras
- IRCCS Santa Lucia Foundation, Neuropsychiatry Laboratory
- Fengyu Zhang
- Lieber Institute for Brain Development, Johns Hopkins University Medical Campus
- Joel E. Kleinman
- Lieber Institute for Brain Development, Johns Hopkins University Medical Campus
- Thomas M. Hyde
- Lieber Institute for Brain Development, Johns Hopkins University Medical Campus
- Sanne S. Kaalund
- Research Laboratory for Stereology and Neuroscience, Bispebjerg University Hospital
- Maria Pontillo
- Department of Neuroscience, Bambino Gesù Children’s Hospital
- Genny Orso
- IRCCS E. Medea Scientific Institute
- Carlo Caltagirone
- IRCCS Santa Lucia Foundation, Neuropsychiatry Laboratory
- Emiliana Borrelli
- University of California
- Maria A. De Luca
- Department of Biomedical Sciences, Università di Cagliari
- Stefano Vicari
- Department of Neuroscience, Bambino Gesù Children’s Hospital
- Daniel R. Weinberger
- Lieber Institute for Brain Development, Johns Hopkins University Medical Campus
- Gianfranco Spalletta
- IRCCS Santa Lucia Foundation, Neuropsychiatry Laboratory
- Francesco Papaleo
- Department of Neuroscience and Brain Technologies, Genetics of Cognition laboratory, Istituto Italiano di Tecnologia
- DOI
- https://doi.org/10.1038/s41467-018-04711-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Patients with schizophrenia show varied response to antipsychotics. Here, the authors demonstrate in patients under antipsychotics treatment that a haplotype associated with lower dysbindin-1 expression correlated with better executive functions, providing further mechanistic support from mouse models.
