Effect of coffee constituents, caffeine and caffeic acid on anxiety and lipopolysaccharide-induced sickness behavior in mice

Jayesh Mudgal; Sanchari Basu Mallik; Madhavan Nampoothiri; Manas Kinra; Susan Hall; Gary D. Grant; Shailendra Anoopkumar-Dukie; Andrew K. Davey; C. Mallikarjuna Rao; Devinder Arora

Journal of Functional Foods (Jan 2020)

Effect of coffee constituents, caffeine and caffeic acid on anxiety and lipopolysaccharide-induced sickness behavior in mice

Jayesh Mudgal,
Sanchari Basu Mallik,
Madhavan Nampoothiri,
Manas Kinra,
Susan Hall,
Gary D. Grant,
Shailendra Anoopkumar-Dukie,
Andrew K. Davey,
C. Mallikarjuna Rao,
Devinder Arora

Affiliations

Jayesh Mudgal: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India
Sanchari Basu Mallik: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India; School of Pharmacy and Pharmacology, MHIQ, QUM Network, Griffith University, Gold Coast, Australia
Madhavan Nampoothiri: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India
Manas Kinra: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India
Susan Hall: School of Pharmacy and Pharmacology, MHIQ, QUM Network, Griffith University, Gold Coast, Australia
Gary D. Grant: School of Pharmacy and Pharmacology, MHIQ, QUM Network, Griffith University, Gold Coast, Australia
Shailendra Anoopkumar-Dukie: School of Pharmacy and Pharmacology, MHIQ, QUM Network, Griffith University, Gold Coast, Australia
Andrew K. Davey: School of Pharmacy and Pharmacology, MHIQ, QUM Network, Griffith University, Gold Coast, Australia
C. Mallikarjuna Rao: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India
Devinder Arora: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India; School of Pharmacy and Pharmacology, MHIQ, QUM Network, Griffith University, Gold Coast, Australia; Corresponding author at: School of Pharmacy and Pharmacology, Gold Coast campus, Griffith University, Queensland 4222, Australia.

Journal volume & issue: Vol. 64
p. 103638

Abstract

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Caffeine (CAF) and polyphenolic compounds like caffeic acid (CA), chlorogenic acid and ferulic acid are commonly consumed through beverages and food. These constituents modulate immune system and impact the systemic inflammatory pathways. This study explored the modulatory effect of CA and CA + CAF on behavior and lipopolysaccharide (LPS) – induced neuroinflammation in mice. An array of behavioral tests suggest that CA (15 mg/kg) and CA + CAF (10 mg/kg + 5 mg/kg) express anxiolytic-like properties. Systemic administration of LPS (1.5 mg/kg) induced profound immobility, increased the systemic/brain cytokine (TNF-α and IL-6) levels and altered the host antioxidant defence in all the animals. Seven days pretreatment with CA alone and CA + CAF significantly reversed the LPS-induced behavioral changes and inflammatory markers. Our results suggest that the low doses of CA may offer a comparable anxiolytic and antidepressant effect when combined with CAF.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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Abstract

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