Sorghum condensed tannins encapsulated in kafirin microparticles as a nutraceutical for inhibition of amylases during digestion to attenuate hyperglycaemia

Malory R. Links; Janet Taylor; Marlena C. Kruger; John R.N. Taylor

Journal of Functional Foods (Jan 2015)

Sorghum condensed tannins encapsulated in kafirin microparticles as a nutraceutical for inhibition of amylases during digestion to attenuate hyperglycaemia

Malory R. Links,
Janet Taylor,
Marlena C. Kruger,
John R.N. Taylor

Affiliations

Malory R. Links: Institute for Food, Nutrition and Well-being, Department of Food Science, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa
Janet Taylor: Institute for Food, Nutrition and Well-being, Department of Food Science, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa
Marlena C. Kruger: Institute for Food, Nutrition and Well-being, Department of Food Science, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa; Institute of Food, Nutrition and Human Health, Massey University, Private Bag 11222, Palmerton North 4442, New Zealand; Department of Human Nutrition, University of Pretoria, P.O. Box 667, Pretoria 0001, South Africa
John R.N. Taylor: Institute for Food, Nutrition and Well-being, Department of Food Science, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa; Corresponding author. Institute for Food, Nutrition and Well-being and Department of Food Science, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa. Tel.: +27 124204296; fax: +27 124202839.

Journal volume & issue: Vol. 12
pp. 55 – 63

Abstract

Read online

Type 2 diabetes (T2D) is increasing rapidly in Africa. An appropriate therapeutic approach is to inhibit intestinal carbohydrate digesting enzymes using plant polyphenols. A crude preparation of sorghum condensed tannins (SCT) was highly effective (approx. 20,000 times) at inhibiting α-glucosidase compared to acarbose, while acarbose was a better α-amylase inhihitor (approx. 180 times). Kafirin microparticles (KEMS) were investigated as an oral delivery system for SCT. Using a simple aqueous alcohol coacervation method, the encapulation efficiency of SCT in the KEMS was approx. 48%. Quantitative data and electron microscopy revealed that KEMS encapsulating SCT were digested to only a limited extent during simulated gastrointestinal digestion with pepsin and trypsin–chymotrypsin. Hence, SCT encapsulated in KEMS retained their inhibitory activity against both amylases, throughout simulated gastrointestinal digestion, whereas unencapsulated SCT lost most of their inhibitory activity. Thus, KEMS encapsulating SCT have potential as a nutraceutical to attenuate hyperglycaemia and control T2D.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

About the journal

Abstract

Keywords