Force-induced repolarization of an active crawler

Abstract

We develop a quantitative model of mechanical repolarization in a contraction-driven gel layer mimicking a crawling cell. We show that the force-velocity relations for such active crawlers exhibit multi-valuedness and hysteresis under both force and velocity control. The model predicts steady oscillations of cells attached to an elastic environment and offers a self-consistent mechanical explanation for all experimentally observed outcomes of cell collision tests.

Keywords

• cell crawling
• active gel
• active particle
• force-velocity relations
• contact inhibition of locomotion
• cell oscillations