EGCG regulates fatty acid metabolism of high-fat diet-fed mice in association with enrichment of gut Akkermansia muciniphila

Abstract

This study is to examine the effects of EGCG on fatty acid metabolism and their possible relationship with gut microbiota. C57BL/6J mice fed with HFD were administrated with 210 mg/kg EGCG for 12 weeks. EGCG significantly decreased saturated fatty acids (C17:0 and C22:0), increased the unsaturated fatty acids (C18:1 and C18:2) (p 0.45 or r < -0.45). Interestingly, Akkermansia muciniphila was positively correlated with C18:2 (p < 0.05, r = 0.51) and negatively correlated with C22:0 (p < 0.05, r = -0.48). These findings demonstrate that alteration of the circulating long chain fatty acids profile is involved in EGCG-mediated lipid metabolism of HFD-fed mice, and the intestinal Akkermansia muciniphila bacteria might play an important role in this process.

Keywords

• EGCG
• Fat accumulation
• Fatty acids metabolism
• Gut microbiota
• Akkermansia muciniphila