Green tea catechins adsorbed on the murine pharyngeal mucosa reduce influenza A virus infection

Shintaro Onishi; Takuya Mori; Hidetoshi Kanbara; Taichi Habe; Noriyasu Ota; Yuki Kurebayashi; Takashi Suzuki

Journal of Functional Foods (May 2020)

Green tea catechins adsorbed on the murine pharyngeal mucosa reduce influenza A virus infection

Shintaro Onishi,
Takuya Mori,
Hidetoshi Kanbara,
Taichi Habe,
Noriyasu Ota,
Yuki Kurebayashi,
Takashi Suzuki

Affiliations

Shintaro Onishi: Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan; Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan
Takuya Mori: Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan; Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan; Corresponding author at: Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan.
Hidetoshi Kanbara: Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan
Taichi Habe: Analytical Science Research, Kao Corporation, 1334 Minato, Wakayama-shi, Wakayama 640-8580 Japan
Noriyasu Ota: Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan
Yuki Kurebayashi: Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan
Takashi Suzuki: Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan

Journal volume & issue: Vol. 68
p. 103894

Abstract

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Green tea consumption reduces influenza incidence in human populations. However, where and how green tea exerts its anti-viral activities remain unclear. Here, we examined the adsorption of green tea catechins on the pharyngeal mucosa at 3–60 min after ingestion of green tea extract (GTE) and the role this adsorption plays in preventing influenza A virus (IAV) infection in BALB/c mice. Green tea catechins were adsorbed on the pharyngeal mucosa for up to 60 min after GTE ingestion. The anti-IAV activity of GTE was dose dependent (p < 0.001). The anti-IAV activity of GTE peaked at 3 min after GTE ingestion and then gradually diminished; this was consistent with the amount of green tea catechins remaining on the pharyngeal mucosa. These results suggest that adsorption of green tea catechins on the pharyngeal mucosa is important for the anti-IAV activity of GTE.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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