Inhibitory effects of antioxidant vitamins against thiyl radical-induced trans fatty acid formation in PC-12 cells

Wei-Lun Hung; Bo-Yang Hsu; Yen-Chen Tung; Chi-Tang Ho; Lucy Sun Hwang

Journal of Functional Foods (Mar 2016)

Inhibitory effects of antioxidant vitamins against thiyl radical-induced trans fatty acid formation in PC-12 cells

Wei-Lun Hung,
Bo-Yang Hsu,
Yen-Chen Tung,
Chi-Tang Ho,
Lucy Sun Hwang

Affiliations

Wei-Lun Hung: Department of Food Science, Rutgers University, 65 Dudley Rd., New Brunswick, NJ 08901, USA; Graduate Institute of Food Science and Technology, National Taiwan University, 1, Section 4, Roosevelt Rd., Taipei 106, Taiwan
Bo-Yang Hsu: Department of Food and Beverage Management, University of Kang Ning, 188, Section 5, Anzhong Rd., Tainan 709, Taiwan
Yen-Chen Tung: Department of Food Science, Rutgers University, 65 Dudley Rd., New Brunswick, NJ 08901, USA
Chi-Tang Ho: Department of Food Science, Rutgers University, 65 Dudley Rd., New Brunswick, NJ 08901, USA; Corresponding author. Department of Food Science, Rutgers University, 65 Dudley Rd., New Brunswick, NJ 08901, USA. Tel.: +1 848 932 5553; fax: +1-732-932-6776.
Lucy Sun Hwang: Graduate Institute of Food Science and Technology, National Taiwan University, 1, Section 4, Roosevelt Rd., Taipei 106, Taiwan; Corresponding author. Graduate Institute of Food Science and Technology, National Taiwan University, No.1, Sec. 4, Roosevelt Rd., Taipei 106, Taiwan. Tel.: +886 2 23629984; fax: +886-2-33664113.

Journal volume & issue: Vol. 21
pp. 212 – 222

Abstract

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Alzheimer's disease (AD) is the most common form of dementia. It is characterized by aggregation of amyloid plaques and neurofibrillary tangles. The neurotoxic action of amyloid β-peptide (Aβ) involves formation of reactive oxygen species. Trans fatty acids (TFAs) are not only exogenously derived from dietary food, but also endogenously formed by free radicals. Thus, we utilized the PC-12 cell model to investigate the correlation between radical stress and endogenous formed TFAs. The results showed that thiyl radicals significantly increased TFA formation in PC-12 cells in both pre-treatment and co-treatment experiments. It was also found that retinol acetate significantly decreased thiyl radical-catalysed TFA formation in PC-12 cells. The anti-isomerization activity of retinol acetate resulted, at least in part, from its high absorption efficiency by PC-12 cells and its thiyl radical scavenging activity. Therefore, retinol acetate may serve as a potential antioxidant for functional foods against TFA formation during pathogenesis of AD.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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