Ameliorative effect of Lactobacillus plantarum WW-fermented soy extract on rat fatty liver via the PPAR signaling pathway

Abstract

The effects of soy extract fermented by Lactobacillus plantarum WW (L. plantarum WW) on high fat diet (HFD)-induced hyperlipidemia and liver injury were examined. Sprague-Dawley rats were randomly divided into normal chow (C), HFD and HFD + L. plantarum WW-fermented soy extract (HFD + FSE). We found that L. plantarum WW-FSE treatment significantly restored changes to body weight and pathological indices caused by fatty liver disease. RNA-seq analysis showed that treatment with L. plantarum WW-FSE altered expression of genes involved in lipid metabolism, and in oxidation-reduction processes. This study supported that the peroxisome proliferator-activated receptor (PPAR) signaling pathway may be involved in lipid metabolism, and suggested that dietary L. plantarum WW-FSE ameliorates HFD-induced lipid metabolism disturbance in rat liver associated with PPAR signaling pathway. These observations shed new light on possible treatment of hyperlipidemia.

Keywords

• Sprague-Dawley rat
• Liver injury
• Transcriptional regulation
• Lipid metabolism