Lactobacillus helveticus-MIKI-020 enhances hepatic FGF21 expression and decreases the core body temperature during sleep in mice

Kohei Kiriyama; Tsuyoshi Goto; Hirotaka Yamamoto; Takeshi Ara; Haruya Takahashi; Huei-Fen Jheng; Wataru Nomura; Hiroyasu Inoue; Rieko Nakata; Teruo Kawada

Journal of Functional Foods (Mar 2019)

Lactobacillus helveticus-MIKI-020 enhances hepatic FGF21 expression and decreases the core body temperature during sleep in mice

Kohei Kiriyama,
Tsuyoshi Goto,
Hirotaka Yamamoto,
Takeshi Ara,
Haruya Takahashi,
Huei-Fen Jheng,
Wataru Nomura,
Hiroyasu Inoue,
Rieko Nakata,
Teruo Kawada

Affiliations

Kohei Kiriyama: Institute for Health Science, MIKI Corporation, Nishinomiya, Hyogo, Japan
Tsuyoshi Goto: Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan; Research Unit for Physiological Chemistry, The Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Uji, Kyoto, Japan; Corresponding author at: Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan.
Hirotaka Yamamoto: Institute for Health Science, MIKI Corporation, Nishinomiya, Hyogo, Japan
Takeshi Ara: Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
Haruya Takahashi: Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
Huei-Fen Jheng: Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
Wataru Nomura: Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan; Research Unit for Physiological Chemistry, The Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Uji, Kyoto, Japan
Hiroyasu Inoue: Department of Food Science and Nutrition, Nara Women's University, Nara, Japan
Rieko Nakata: Department of Food Science and Nutrition, Nara Women's University, Nara, Japan
Teruo Kawada: Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan; Research Unit for Physiological Chemistry, The Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Uji, Kyoto, Japan

Journal volume & issue: Vol. 54
pp. 529 – 535

Abstract

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The onset of sleep has been reported to be accompanied by a decline in the core body temperature (CBT) at the onset of night. The stimulation of hepatic FGF21 by PPARα agonist influences the central nervous system and decreases the CBT. The present study aimed to evaluate the effect of food-derived PPARα activator on hepatic FGF21 expression and CBT regulation using Lactobacillus helveticus-MIKI-020 (LH). The treatment with LH stimulated FGF21 expression in a PPARα-dependent manner in hepatocytes. Furthermore, two weeks of LH treatment decreased the CBT only during sleep in mice. The expression of FGF21 in the liver and the plasma content of FGF21 were significantly higher in the LH feeding group than in the control group. The results present a novel approach to decrease the CBT during sleep, which can potentially improve sleep disorders.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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