The monomer of resveratrol butyrate ester ameliorates obesity and gut microbiota in high-fat diet rats

Yu-Wei Chen; Rou-Yun Liu; Ming-Kuei Shih; Wen-Wei Lin; Chiu-Min Cheng; Chang-Wei Hsieh; Chih-Yao Hou; Shin-Yu Chen

Journal of Functional Foods (Jul 2024)

The monomer of resveratrol butyrate ester ameliorates obesity and gut microbiota in high-fat diet rats

Yu-Wei Chen,
Rou-Yun Liu,
Ming-Kuei Shih,
Wen-Wei Lin,
Chiu-Min Cheng,
Chang-Wei Hsieh,
Chih-Yao Hou,
Shin-Yu Chen

Affiliations

Yu-Wei Chen: Department of Medicine, Chang Gung University, Taoyuan 333, Taiwan; Department of Food Science and Biotechnology, National Chung Hsing University, Taichung 145, Taiwan
Rou-Yun Liu: Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 811, Taiwan
Ming-Kuei Shih: Graduate Institute of Food Culture and Innovation, National Kaohsiung University of Hospitality and Tourism, Kaohsiung 812, Taiwan
Wen-Wei Lin: Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Chiu-Min Cheng: Department of Aquaculture, National Kaohsiung University of Science and Technology, Kaohsiung 811, Taiwan
Chang-Wei Hsieh: Department of Food Science and Biotechnology, National Chung Hsing University, Taichung 145, Taiwan
Chih-Yao Hou: Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 811, Taiwan; Corresponding author at: Department of Seafood Science, National Kaohsiung University of Science and Technology, No.142, Haijhuan Rd., Nanzih Dist., Kaohsiung City 81157, Taiwan.
Shin-Yu Chen: Department of Food Science, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan; Corresponding author at: Department of Food Science, National Pingtung University of Science and Technology, 1 Shuefu Road, Neipu, Pingtung 91201, Taiwan.

Journal volume & issue: Vol. 118
p. 106260

Abstract

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Resveratrol butyrate ester (RBE), synthesized via the esterification of resveratrol and butyric acid, demonstrates better bioactivity than resveratrol. Therefore, we evaluated the anti-obesity effects of two RBE monomers with different numbers of ester, mono-ester derivative (3-O-butanoylresveratrol, ED4) and di-ester derivative (3,4′-di-O-butanoylresveratrol, ED2) in obese rats. Animals were assigned to the control diet, high-fat diet (HFD), HFD with ED4 (HFDM), and HFD with ED2 (HFDD) groups. After 6 weeks of treatment, the groups treated with ED4 and ED2 effectively regulated their basic biochemical indicators, including body weight and lipid parameters in serum and liver. Moreover, supplementation with ED4 and ED2 decreased the ratio of Firmicutes to Bacteroidetes and altered the levels of short-chain fatty acids, which may contribute to the anti-obesity effects. This research showcases the potential of RBE monomers in obesity prevention, particularly highlighting the greater efficacy of mono-ester RBE (ED4) compared to its di-ester form (ED2).

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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