Monogenic Kidney Diseases in Kidney Transplantation

Valentine Gillion; Arnaud Devresse; Eric Olinger; Géraldine Dahlqvist; Nathalie Demoulin; Nathalie Godefroid; Kathleen Claes; Olivier Devuyst; Nada Kanaan

doi:10.1016/j.ekir.2023.12.003

Kidney International Reports (Mar 2024)

Monogenic Kidney Diseases in Kidney Transplantation

Valentine Gillion,
Arnaud Devresse,
Eric Olinger,
Géraldine Dahlqvist,
Nathalie Demoulin,
Nathalie Godefroid,
Kathleen Claes,
Olivier Devuyst,
Nada Kanaan

Affiliations

Valentine Gillion: Department of Nephrology, Cliniques universitaires Saint-Luc, Brussels, Belgium; Institut de Recherche Experimentale et Clinique, Université catholique de Louvain, Brussels, Belgium; Correspondence: Valentine Gillion, Nephrology Department, Cliniques universitaires Saint-Luc, 10, avenue Hippocrate, 1200 Brussels, Belgium.
Arnaud Devresse: Department of Nephrology, Cliniques universitaires Saint-Luc, Brussels, Belgium; Institut de Recherche Experimentale et Clinique, Université catholique de Louvain, Brussels, Belgium; Surgery and Abdominal Transplant Unit, University Clinics Saint Luc, Université Catholique de Louvain, Brussels, Belgium
Eric Olinger: Center for Human Genetics, Cliniques universitaires Saint-Luc, Brussels, Belgium
Géraldine Dahlqvist: Institut de Recherche Experimentale et Clinique, Université catholique de Louvain, Brussels, Belgium; Liver Transplant Unit, Cliniques universitaires Saint-Luc, Brussels, Belgium
Nathalie Demoulin: Department of Nephrology, Cliniques universitaires Saint-Luc, Brussels, Belgium; Institut de Recherche Experimentale et Clinique, Université catholique de Louvain, Brussels, Belgium
Nathalie Godefroid: Institut de Recherche Experimentale et Clinique, Université catholique de Louvain, Brussels, Belgium; Department of Pediatric Nephrology, Cliniques universitaires Saint-Luc, Brussels, Belgium
Kathleen Claes: Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
Olivier Devuyst: Department of Nephrology, Cliniques universitaires Saint-Luc, Brussels, Belgium; Institut de Recherche Experimentale et Clinique, Université catholique de Louvain, Brussels, Belgium; Institute of Physiology, University of Zurich, Zurich, Switzerland
Nada Kanaan: Department of Nephrology, Cliniques universitaires Saint-Luc, Brussels, Belgium; Institut de Recherche Experimentale et Clinique, Université catholique de Louvain, Brussels, Belgium

DOI: https://doi.org/10.1016/j.ekir.2023.12.003
Journal volume & issue: Vol. 9, no. 3
pp. 549 – 568

Abstract

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Monogenic kidney diseases are involved in up to 15% of end-stage kidney diseases (ESKDs) in adults, and in 70 % of pediatric patients. When these disorders lead to kidney failure (KF), kidney transplantation (KT) is the preferred mode of replacement therapy. KT requires specific considerations depending on the nature of the genetic disorder, the potential oncological risk, the risk of recurrence in the graft, the possibility of specific complications of immunosuppression, and the issue of living donation. The availability of genetic testing should play an increasing role in the evaluation of patients or related living donor candidates before transplantation, relevant for the pretransplantation and posttransplantation management.

Published in Kidney International Reports

ISSN: 2468-0249 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology
Website: https://www.sciencedirect.com/journal/kidney-international-reports

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