A review of clinical and preclinical data supporting a role for resveratrol in the treatment of common respiratory tract pathogens
Giulio Dinardo,
Michele Miraglia del Giudice,
Lorenzo Drago,
Maria Daglia,
Alessandra Gori,
Attilio Varricchio,
Chiara Trincianti,
Enrico Tondina,
Francesco Paolo Brunese,
Giulia Brindisi,
Matteo Naso,
Anna Maria Zicari,
Giorgio Ciprandi,
Cristiana Indolfi
Affiliations
Giulio Dinardo
Department of Woman, Child and General and Specialized Surgery, University of Campania ''Luigi Vanvitelli'', Naples, Italy; Corresponding author.
Michele Miraglia del Giudice
Department of Woman, Child and General and Specialized Surgery, University of Campania ''Luigi Vanvitelli'', Naples, Italy
Lorenzo Drago
Laboratory of Clinical Microbiology & Microbiome, Department of Biomedical Sciences for Health, University of Milan, Italy; UOC Laboratory of Clinical Medicine, MultiLab Department, IRCCS Multimedica, Milan, Italy
Maria Daglia
Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 2013, China
Alessandra Gori
Department of Maternal Infantile and Urological Science, Sapienza University of Rome, 00161 Rome, Italy
Attilio Varricchio
Department of Otolaryngology, University of Molise, 86100 Campobasso, Italy
Chiara Trincianti
Allergy Center, IRCCS Istituto Giannina Gaslini, Genoa, Italy
Enrico Tondina
Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
Francesco Paolo Brunese
Primary Care Paediatrics, ASL Caserta, Caserta, Italy
Giulia Brindisi
Department of Maternal Infantile and Urological Science, Sapienza University of Rome, 00161 Rome, Italy
Matteo Naso
Allergy Center, IRCCS Istituto Giannina Gaslini, Genoa, Italy
Anna Maria Zicari
Department of Maternal Infantile and Urological Science, Sapienza University of Rome, 00161 Rome, Italy
Giorgio Ciprandi
Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy
Cristiana Indolfi
Department of Woman, Child and General and Specialized Surgery, University of Campania ''Luigi Vanvitelli'', Naples, Italy
Respiratory infections are a relevant issue during infancy and childhood, constituting a major source of morbidity and imposing a substantial burden on healthcare systems. Conditions such as bronchiolitis, pneumonia, and influenza exemplify the gravity of these infections among pediatric populations. In the context of this health challenge, resveratrol, a naturally occurring polyphenolic antioxidant has emerged as a focal point of extensive research, known for its antioxidant, anti-inflammatory, and antimicrobial properties. This comprehensive review delves into the compound's extensive antimicrobial activities against a diverse range of bacteria and viruses, both as a standalone agent and in combination with conventional antibiotics. This compound exhibits notable antiviral activity against viruses implicated in severe respiratory infections, offering a potential therapeutic avenue. By exploring the antiviral mechanisms and highlighting the anti-inflammatory potential of resveratrol, this comprehensive overview contributes to a deeper understanding of its applicability in mitigating the complexities associated with pediatric respiratory infections.
