Functional Significance and Structure-Activity Relationship of Food-Derived Protein Tyrosine Phosphatase 1B Inhibitors

Abstract

Protein tyrosine phosphatase 1B (PTP1B), a potential target for the treatment of type 2 diabetes and obesity, plays a key negative regulatory role in the insulin and leptin signaling pathways. Natural products, with structural diversity, can affect different targets and pathways to exert their unique preventive and therapeutic effects on diabetes or its complications. Various food-derived natural products have been reported for their PTP1B inhibitory activity in recent years. This article mainly overviews recent progress in understanding the mechanism of action of PTP1B and food-derived natural PTP1B inhibitors, which will hopefully provide a theoretical rationale for further research on PTP1B inhibitors and the development of new PTP1B inhibitors or hypoglycemic functional foods.

Keywords

• food-derived; natural compounds; type 2 diabetes; protein tyrosine phosphatase 1b inhibitor