The soybean bioactive peptide VHVV alleviates hypertension-induced renal damage in hypertensive rats via the SIRT1-PGC1α/Nrf2 pathway

Bruce Chi-Kang Tsai; Wei-Wen Kuo; Cecilia Hsuan Day; Dennis Jine-Yuan Hsieh; Chia-Hua Kuo; Jayasimharayalu Daddam; Ray-Jade Chen; V. Vijaya Padma; Guiqing Wang; Chih-Yang Huang

Journal of Functional Foods (Dec 2020)

The soybean bioactive peptide VHVV alleviates hypertension-induced renal damage in hypertensive rats via the SIRT1-PGC1α/Nrf2 pathway

Bruce Chi-Kang Tsai,
Wei-Wen Kuo,
Cecilia Hsuan Day,
Dennis Jine-Yuan Hsieh,
Chia-Hua Kuo,
Jayasimharayalu Daddam,
Ray-Jade Chen,
V. Vijaya Padma,
Guiqing Wang,
Chih-Yang Huang

Affiliations

Bruce Chi-Kang Tsai: Graduate Institute of Aging Medicine, China Medical University, Taichung, Taiwan; Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan
Wei-Wen Kuo: Department of Biological Science and Technology, China Medical University, Taichung, Taiwan
Cecilia Hsuan Day: Department of Nursing, Mei Ho University, Neipu, Pingtung, Taiwan
Dennis Jine-Yuan Hsieh: School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan; Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan
Chia-Hua Kuo: Department of Sports Sciences, University of Taipei, Taipei, Taiwan
Jayasimharayalu Daddam: Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan
Ray-Jade Chen: Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
V. Vijaya Padma: Department of Biotechnology, Bharathiar University, Coimbatore, India
Guiqing Wang: Department of Orthopedics, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan, Guangdong, China
Chih-Yang Huang: Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan; Department of Biological Science and Technology, Asia University, Taichung, Taiwan; Corresponding author at: Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien, Taiwan.

Journal volume & issue: Vol. 75
p. 104255

Abstract

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Hypertension triggers oxidative stress, causing dysfunction in organs, including the brain, heart, and kidney. In this study, we examined the potential renal benefit of the soybean bioactive peptide VHVV by in silico analysis and in spontaneously hypertensive rats. Sixteen-week-old spontaneously hypertensive rats were divided into 3 groups and treated with or without VHVV or captopril. Age-matched Wistar-Kyoto rats were used as normotensive control group. The rats were sacrificed after 8 weeks of treatment, and kidneys were analyzed to demonstrate the efficacy of VHVV. In silico analysis confirmed the antihypertensive activity of VHVV. In animal study, VHVV induced antioxidant defense and modulated mitochondrial homeostasis in the hypertensive kidney via SIRT1-PGC1α/Nrf2 pathway. Hence, improvements in renal cells were attributed to the suppression of inflammation and apoptosis, and the architecture of the hypertensive kidney was restored after peptide treatment. Overall, VHVV exhibited therapeutic effects by decreasing renal damage caused by hypertension-induced free radicals.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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