Journal of Acute Disease (Jan 2013)

Study of hepatic histomorphology in HBeAg+ and HBeAg− patients with CHB: Experience from Bangladesh

  • Ayub Al Mamun,
  • Mamun-Al-Mahtab,
  • S.M. Fazle Akbar,
  • Kutub Uddin Mollick,
  • Arun Jyoti Tarafdar,
  • Faiz Ahmad Khondokar,
  • Ahmed Lutful Mubin,
  • Md. Helal Uddin,
  • Salimur Rahman

DOI
https://doi.org/10.1016/S2221-6189(13)60133-X
Journal volume & issue
Vol. 2, no. 3
pp. 232 – 235

Abstract

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Objective: To compare Knodell and HAI scores in patients with wild type and pre-core/core promoter mutant CHB to see if there is any difference in severity of liver injury between these two types of HBV. Methods: We did percutaneous liver biopsies of 155 CHB patients. Of them 102 (65.8%) were infected wild type HBV and the rest 53 (34.2%) were infected with pre-core/core promoter mutant CHB. Results: 11/53 (20.8%) patients with pre-core/core promoter mutant CHB had moderate to severe CH (HAI score 8-18). In contrast, moderate to severe CH was seen in 19/102 (18.6%) patients with wild type CHB. Fibrosis score was >2 in 15/53 (28.3%) pre-core/core promoter mutant CHB as opposed to 20/102 (19.6%) patients with wild type CHB. Conclusions: The study shows that pre-core/core promoter mutant HBV produces more severe histological liver disease compared to wild type HBV.

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