Partial efficacy of Yuzu (Citrus junos) pectin side chains in elongating the jejunal villus in protein-deficient malnourished mice

Abstract

Pectin, a soluble fiber, can induce elongation of the intestinal villi. However, the relationship between pectin-induced villus elongation and nutrient absorption remains unclear. Therefore, we investigated whether pectin could mitigate malnutrition by enhancing nutrient absorption. We specifically utilized Yuzu pectin side chains, which were chosen for their potential in preventing nutrient absorption inhibition, to examine their effects on elongation of the villus in protein-deficient, mildly malnourished mice. These side chains exerted contrasting effects on the spleen and liver, both of which atrophied owing to a low-protein diet, preventing a decrease in spleen weight. The administration of side chains suppressed liver lipid accumulation; however, triglyceride and cholesterol levels were increased. Although these side chains extended the jejunal villi, they could not completely alleviate malnutrition. This study establishes a crucial foundation for further elucidating the physiological relevance of the pectin-induced morphological alterations in the small intestinal villus and advancing its practical applications.

Keywords

• Pectin
• Small intestinal villus
• Nutrient absorption
• Malnutrition
• Protein deficiency