Coreopsis tinctoria flowers extract ameliorates D-galactose induced aging in mice via regulation of Sirt1-Nrf2 signaling pathway

Yong Tian; Zhen Wen; Lin Lei; Fuhua Li; Jichun Zhao; Qi Zhi; Fuxiang Li; Ran Yin; Jian Ming

Journal of Functional Foods (Sep 2019)

Coreopsis tinctoria flowers extract ameliorates D-galactose induced aging in mice via regulation of Sirt1-Nrf2 signaling pathway

Yong Tian,
Zhen Wen,
Lin Lei,
Fuhua Li,
Jichun Zhao,
Qi Zhi,
Fuxiang Li,
Ran Yin,
Jian Ming

Affiliations

Yong Tian: College of Food Science, Southwest University, Chongqing 400715, People’s Republic of China
Zhen Wen: Department of General Surgery, Chengdu Third People's Hospital, Chengdu 610031, People’s Republic of China
Lin Lei: College of Food Science, Southwest University, Chongqing 400715, People’s Republic of China
Fuhua Li: College of Food Science, Southwest University, Chongqing 400715, People’s Republic of China; Chongqing Engineering Research Center for Special Foods, Chongqing 400715, People’s Republic of China
Jichun Zhao: College of Food Science, Southwest University, Chongqing 400715, People’s Republic of China; Chongqing Engineering Research Center for Special Foods, Chongqing 400715, People’s Republic of China
Qi Zhi: College of Food Science, Southwest University, Chongqing 400715, People’s Republic of China
Fuxiang Li: College of Food Science, Southwest University, Chongqing 400715, People’s Republic of China
Ran Yin: Ernest Mario School of Pharmacy, Rutgers University, 160 Frelinghuysen Rd, Piscataway Township, NJ 008854, USA
Jian Ming: College of Food Science, Southwest University, Chongqing 400715, People’s Republic of China; Chongqing Engineering Research Center for Special Foods, Chongqing 400715, People’s Republic of China; Corresponding author at: College of Food Science, Southwest University, Tiansheng Road 2, Chongqing 400715, People’s Republic of China.

Journal volume & issue: Vol. 60

Abstract

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The aim of this study was to investigate the protective effects and its underlying signaling pathways of Coreopsis tinctoria flowers extract (CTE) on D-galactose induced aging in mice. UPLC/Q-TOF-MS analysis of CTE identified 12 active compounds, including three phenolic acids and nine flavonoids. The extract showed superior antioxidant activities in vitro using DPPH, FRAP, and ORAC assay. Administration with CTE remarkably improved body weight, organ indexes of aging mice, and liver histological injury as well as decreased oxidative stress markers levels of aged mice. Further studies showed CTE treatment significantly enhanced Sirt1 expression and activated the Nrf2 signaling pathway by the increase of Nrf2 nuclear translocation, NQO-1 and HO-1 expression. Furthermore, CTE treatment resulted in the increase of Sirt3 and the suppression of p53. These results demonstrated that the promising anti-aging effects of Coreopsis tinctoria flowers extract might be related to up-regulation of Sirt1-Nrf2 signaling pathway.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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