A standardized notoginseng extract exerts cardioprotection by attenuating apoptosis under endoplasmic reticulum stress conditions

Li-Chao Wang; Wen-Song Zhang; Qun Liu; Jia Li; Raphael N. Alolga; Kang Liu; Bao-Lin Liu; Ping Li; Lian-Wen Qi

Journal of Functional Foods (Jun 2015)

A standardized notoginseng extract exerts cardioprotection by attenuating apoptosis under endoplasmic reticulum stress conditions

Li-Chao Wang,
Wen-Song Zhang,
Qun Liu,
Jia Li,
Raphael N. Alolga,
Kang Liu,
Bao-Lin Liu,
Ping Li,
Lian-Wen Qi

Affiliations

Li-Chao Wang: State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, China
Wen-Song Zhang: State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, China
Qun Liu: State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, China
Jia Li: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, China
Raphael N. Alolga: State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, China
Kang Liu: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, China
Bao-Lin Liu: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, China
Ping Li: State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, China; Corresponding author. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Tel.: +86 25 83271379; fax: +86 25 83271379.
Lian-Wen Qi: State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, China; Corresponding author. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Tel.: +86 25 83271379; fax: +86 25 83271379.

Journal volume & issue: Vol. 16
pp. 20 – 27

Abstract

Read online

Panax notoginseng possesses therapeutic potential for cardiovascular disorders. Endoplasmic reticulum (ER) stress plays a critical role in cardiovascular disease. Here we show that a rare ginsenoside-standardized extract (RGSE) from notoginseng exerts cardioprotection via attenuating ER stress-associated apoptosis. A total of 18 ginsenosides with a concentration of 816.75 mg/g were characterized and quantified in RGSE. Ginsenoside Rh4, Rg5, Rk3, and Rk1 were the most abundant. RGSE at 50 and 100 mg/kg significantly attenuated myocardial infarction and improved cardiac function in acute myocardial infarction (AMI). RGSE also prevented myocardial ischemia-induced oxidative stress and apoptosis in vivo and in vitro. In addition, RGSE decreased the overexpression of GRP78, GRP94 and CHOP, and inhibited the phosphorylation of PERK and IRE1α in ER stress. Further investigation revealed that RGSE effectually inactivated TXNIP/NLRP3 signaling pathway in AMI hearts. These observations suggest a novel role for notoginseng in regulating AMI.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

About the journal

Abstract

Keywords