Protective effects of catechin (C) and epigallocatechin gallate (EGCG) against high-fat diet (HFD)-exacerbated Salmonella infection in mice

Jingli Cheng; Mingxue Yang; Tingbo Wu; Puming He; Yuanyuan Wu; Bo Li; Youying Tu; Xiaochun Wan; Junsheng Liu

Journal of Functional Foods (Sep 2024)

Protective effects of catechin (C) and epigallocatechin gallate (EGCG) against high-fat diet (HFD)-exacerbated Salmonella infection in mice

Jingli Cheng,
Mingxue Yang,
Tingbo Wu,
Puming He,
Yuanyuan Wu,
Bo Li,
Youying Tu,
Xiaochun Wan,
Junsheng Liu

Affiliations

Jingli Cheng: Department of Tea Science, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, Zhejiang, PR China
Mingxue Yang: Department of Tea Science, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, Zhejiang, PR China
Tingbo Wu: Department of Tea Science, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, Zhejiang, PR China
Puming He: Department of Tea Science, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, Zhejiang, PR China
Yuanyuan Wu: Department of Tea Science, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, Zhejiang, PR China
Bo Li: Department of Tea Science, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, Zhejiang, PR China
Youying Tu: Department of Tea Science, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, Zhejiang, PR China
Xiaochun Wan: State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei 230036, Anhui, PR China; Corresponding author at: State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei 230036, Anhui, PR China.
Junsheng Liu: State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei 230036, Anhui, PR China; Corresponding author at: Department of Tea Science, Zhejiang University No. 866 Yuhangtang Road, Hangzhou, Zhejiang Province 310058, PR China.

Journal volume & issue: Vol. 120
p. 106389

Abstract

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Salmonella is one of the most prevalent foodborne pathogens. This study investigated the impact of HFD on Salmonella infection and the preventive effects of tea-derived polyphenols. Results showed that HFD decreased the survival rate of Salmonella-infected mice, while catechin (C) and epigallocatechin gallate (EGCG) supplementation increased survival rates, with EGCG being more effective. HFD promoted pro-inflammatory cytokines and inhibited intestinal epithelial barrier proteins, but catechins, especially EGCG, restored these levels. 16S rDNA sequencing revealed HFD-induced gut microbiota disruptions. Both catechins altered bacterial composition and diversity, with distinct profiles for C and EGCG. The relative abundance of Desulfovibrio and the Eubacterium coprostanoligenes group was modulated by both catechins, and nine bacteria were identified as biomarkers for EGCG treatment. In summary, Salmonella infection is exacerbated by HFD, but catechins, particularly EGCG, offer protective effects, providing valuable insights for controlling pathogenic infections by tea polyphenols or related functional foods.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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